25746-83-2

Upstream product

• 73096-29-4 1-(toluene-4-sulfonyl)-L-prolin-anilide 
• 64030-42-8 benzyl (2S)-2-(phenylcarbamoyl)pyrrolidine-1-carboxylate 
• 103-71-9 phenyl isocyanate 
• 62-53-3 aniline 
• 108-86-1 bromobenzene 
• 7531-52-4 L-prolinamide 
• 591-50-4 iodobenzene 
• 15761-39-4 N-tert-butoxycarbonyl-proline 
• 99405-61-5 tert-butyl 2-(phenylcarbamoyl)pyrrolidine-1-carboxylate 
• 2812-47-7 pyrrolidine-2-carboxylic acid amide 
• 220510-58-7 tert-butyl (S)-2-(phenylcarbamoyl)pyrrolidine-1-carboxylate 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 71989-31-6 Fmoc-Pro-OH 
• 403478-34-2 (S)-9H-fluorenylmethyl 2-(phenylcarbamoyl)pyrrolidine-1-carboxylate 

Downstream Products

• 148205-91-8 Z-Gly-Pro-Arg(NO₂)-Pro-aniline 
• 91704-70-0 (+)-(thenoyl-3)-2 phenyl-3 diazabicyclo-1,3<3,3,O>octane 
• 104261-76-9 3-methylene-2-phenyl-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]-[8aS]-pyrazine-1,4-dione 
• 1173169-88-4 C₂₂H₂₆N₂O₂ 
• 1251837-14-5 (S)-3,3-dimethyl-2-phenyl-hexahydropyrrolo[1,2-e]imidazol-1-one 
• 1251837-21-4 (3R,7aS)-3-(4-nitrophenyl)-2-phenylhexahydropyrrolo[1,2-e]imidazol-1-one 
• 1251837-20-3 (3S,7aS)-3-(4-nitrophenyl)-2-phenylhexahydropyrrolo[1,2-e]imidazol-1-one 
• 88958-64-9 1-(4-nitrophenyl)-1-hydroxy-3-butanone 
• 1251837-19-0 C₂₉H₃₁N₅O₄ 
• 1313735-03-3 C₁₈H₂₀N₂O₂ 
• 403617-25-4 C₃₀H₃₃FN₄O₂ 
• 1415831-62-7 (S)-N-isobutyrylproline anilide 
• 1415831-68-3 (S)-2-anilinomethyl-1-neopentylpyrrolidine 

Relevant academic research and scientific papers

Synthesis of Cyanuric Chloride based Chiral Reagent for RP-HPLC Enantioseparation of (RS)-Propranolol

In this work, four cyanuric chloride based chiral reagents were prepared via nucleophile substitution of chlorine atom by L-proline derivatives and characterized by UV, FT-IR, HRMS, NMR and elemental analysis. Racemic propranolol was chosen for the chiral

Design, synthesis, and insecticidal activities of novel diamide derivatives with alpha-amino acid subunits

A series of diamide derivatives containing α-amino acids were designed and synthesized. These compounds were evaluated for their insecticidal activities against Plutella xylostella, Mythimna separate, Myzus persicae, and Tetranychus cinnabarinus. Most of the title compounds containing an l-phenylglycine skeleton were endowed with good activities at the concentration of 500 mg·L?1. Compounds (R)-A6 showed a potential value for further optimization as an insecticidal lead with the LC50 value of 86.8 mg·L?1.

New small γ-turn type: N -primary amino terminal tripeptide organocatalyst for solvent-free asymmetric aldol reaction of various ketones with aldehydes

New small γ-turn type N-primary amino terminal tripeptides were synthesized and their functionality as an organocatalyst was examined in the asymmetric aldol reaction of various ketones with different aromatic aldehydes under solvent-free neat conditions to afford the desired chiral anti-aldol products in good to excellent chemical yields, diastereoselectivities and enantioselectivities (up to 99%, up to syn?:?anti/13?:?87 dr, up to 99% ee). This journal is

Modular synthesis of new bicyclic carbene precursors

A series of new N-heterocyclic carbene (NHC) precursors, containing bicyclic pyrrolo[1,2-c]imidazole framework, were prepared from N-(tert-butoxycarbonyl)-L-proline (1-Boc-L-proline). The sequential attachment of nitrogen nucleophiles and subsequent ring

Chiral azo-heterocyclic carbene precursor compound with bicyclic framework and preparation method thereof

The invention discloses a chiral azo-heterocyclic carbene precursor compound with a bicyclic framework and a preparation method thereof. A series of the chiral azo-heterocyclic carbene precursor compound with the bicyclic framework is obtained by taking c

Amide compounds, preparation method and application thereof

The invention relates to amide compounds shown in formula I, stereoisomers or pharmaceutically acceptable salts thereof. The amide compounds and the stereoisomers or pharmaceutically acceptable saltsthereof according to the invention can inhibit the gener

Synthesis and anticancer activity of conformationally constrained Smac mimetics containing pseudo β turns

Herein, we report synthesis and in vitro anticancer activity of conformationally constrained Smac mimetics containing reverse turn inducing motifs “Ant-Pro” and “sAnt-Pro”. The synthesis of Smac analogs with diverse hydrophobic groups at the C-

"on Water" Promoted Ullmann-Type C-N Bond-Forming Reactions: Application to Carbazole Alkaloids by Selective N-Arylation of Aminophenols

The Ullmann-type cross coupling of a variety of aromatic, aliphatic amines with aryl halides is reported using a CuI-based catalytic system in combination with an easily accessible prolinamide ligand in aqueous media. The method is mild and tolerant to air, moisture, and a wide range of functional groups, providing a novel way to access a variety of aminated products. Secondary amines like heteroaromatic amines and nucleobases have also been used, affording the corresponding coupling products in good to excellent yields. Moreover, this method has been employed for chemoselective C-N arylation of aminophenols and further utilized for the synthesis of carbazole natural products, avoiding the protection and deprotection steps.

Synthesis of chiral α-amino anilides via a DMEDA-promoted selective C─N coupling reaction of aryl halides and α-aminoamides

A DMEDA-promoted and copper-catalyzed approach has been designed for the coupling of aryl halides and chiral α-aminoamides to afford a range of functionalized chiral α-amino anilides. This method has a higher yield and better reproducibility than those under ligand-free conditions. Of the two amino groups in the same molecule, only the amide NH2 is observed to react, showing high regioselectivity. In addition, no racemization occurs, and the ee can reach 99%. For certain hydroxyl-containing substrates, such as L-tyrosine amide and L-threonine amide, addition of a phase transfer catalyst (15-Crown-5) is necessary for such a transformation.

Novel indole derivative and medicine containing the same (by machine translation)

[A] formation of Amyloid fibrils can be compounds, including therapeutic or prophylactic agent for neurodegenerative disease Amyloid fibrils formation inhibitor compound and of. (I) or its pharmaceutically acceptable compound represented by the formula [a] or a salt or solvate thereof includes the, Amyloid fibrils formation inhibitor. [R1 And R2 Each independently is H, an alkyl group, a cyano group or the like; R3 And R4 Each independently is H, or an alkyl group; R3 And R4 The, joint may form a ring; Ar1 And Ar2 The substituted or unsubstituted heteroaryl group are independently substituted/unsubstituted aryl groups /; X and Y are each independently a single bond, - (=O) - C etc., Z is O or CH2 ; N is an integer of 1 - 3][Drawing] no (by machine translation)