Welcome to LookChem.com Sign In|Join Free

CAS

  • or
Methyl 1-isopropyl-1H-indazole-3-carboxylate is a chemical compound with the molecular formula C13H15N2O2. It is a synthetic cannabinoid and an indazole-3-carboxylate derivative that acts as a potent agonist at the cannabinoid receptors CB1 and CB2. Methyl 1-isopropyl-1H-indazole-3-carboxylate is known for its psychoactive effects, including euphoria, relaxation, and altered perception.

173600-05-0

Post Buying Request

173600-05-0 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

173600-05-0 Usage

Uses

Used in Pharmaceutical Industry:
Methyl 1-isopropyl-1H-indazole-3-carboxylate is used as a research chemical for the development of new drugs targeting the cannabinoid receptors CB1 and CB2. Its potent agonist activity makes it a valuable tool in studying the effects of cannabinoids on the human body and their potential therapeutic applications.
Used in Forensic Toxicology:
Methyl 1-isopropyl-1H-indazole-3-carboxylate is used as a reference compound in forensic toxicology to identify and analyze synthetic cannabinoid products. Its presence in various synthetic cannabinoid products helps in understanding the chemical composition and potential risks associated with these substances.
Used in Neuropharmacology Research:
Methyl 1-isopropyl-1H-indazole-3-carboxylate is used as a research compound in neuropharmacology to study the effects of cannabinoids on the central nervous system. Its psychoactive properties, such as euphoria, relaxation, and altered perception, provide insights into the mechanisms of action of cannabinoids and their potential therapeutic uses in treating various neurological disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 173600-05-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,3,6,0 and 0 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 173600-05:
(8*1)+(7*7)+(6*3)+(5*6)+(4*0)+(3*0)+(2*0)+(1*5)=110
110 % 10 = 0
So 173600-05-0 is a valid CAS Registry Number.

173600-05-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 1-isopropyl-1H-indazol-3-ylcarboxylate

1.2 Other means of identification

Product number -
Other names 1-isopropyl-1H-indazole-3-carboxylic acid methyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:173600-05-0 SDS

173600-05-0Relevant articles and documents

Discovery and Preclinical Characterization of Usmarapride (SUVN-D4010): A Potent, Selective 5-HT4Receptor Partial Agonist for the Treatment of Cognitive Deficits Associated with Alzheimer's Disease

Nirogi, Ramakrishna,Mohammed, Abdul Rasheed,Shinde, Anil Karbhari,Gagginapally, Shankar Reddy,Kancharla, Durga Malleshwari,Ravella, Srinivasa Rao,Bogaraju, Narsimha,Middekadi, Vanaja Reddy,Subramanian, Ramkumar,Palacharla, Raghava Choudary,Benade, Vijay,Muddana, Nageswararao,Abraham, Renny,Medapati, Rajesh Babu,Thentu, Jagadeesh Babu,Mekala, Venkat Reddy,Petlu, Surendra,Lingavarapu, Bujji Babu,Yarra, Sivasekhar,Kagita, Narendra,Goyal, Vinod Kumar,Pandey, Santosh Kumar,Jasti, Venkat

supporting information, p. 10641 - 10665 (2021/08/03)

A series of oxadiazole derivatives were synthesized and evaluated as 5-hydroxytryptamine-4 receptor (5-HT4R) partial agonists for the treatment of cognitive deficits associated with Alzheimer's disease. Starting from a reported 5-HT4R antagonist, a systematic structure-activity relationship was conducted, which led to the discovery of potent and selective 5-HT4R partial agonist 1-isopropyl-3-{5-[1-(3-methoxypropyl) piperidin-4-yl]-[1,3,4]oxadiazol-2-yl}-1H-indazole oxalate (Usmarapride, 12l). It showed balanced physicochemical-pharmacokinetic properties with robust nonclinical efficacy in cognition models. It also showed disease-modifying potential, as it increased neuroprotective soluble amyloid precursor protein alpha levels, and dose-dependent target engagement and correlation of efficacy with oral exposures. Phase 1 clinical studies have been completed and projected efficacious concentration was achieved without any major safety concerns. Phase 2 enabling long-term safety studies have been completed with no concerns for further development.

Sulfocoumarin-, Coumarin-, 4-Sulfamoylphenyl-Bearing Indazole-3-carboxamide Hybrids: Synthesis and Selective Inhibition of Tumor-Associated Carbonic Anhydrase Isozymes IX and XII

Angapelly, Srinivas,Sri Ramya,Angeli, Andrea,Supuran, Claudiu T.,Arifuddin, Mohammed

, p. 1578 - 1584 (2017/10/16)

A series of sulfocoumarin-, coumarin-, and 4-sulfamoylphenyl-bearing indazole-3-carboxamide hybrids were synthesized and investigated as inhibitors of the human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms I and II (cytosolic isozymes), as well as hCA IX and XII (transmembrane, tumor-associated enzymes). Compounds 6 a–g (amide derivatives) and 7 a–h (triazoles) act as “prodrugs”, and their hydrolysis products are the de facto CA inhibitors. These compounds displayed sub-micromolar to high-nanomolar inhibitory activity against hCA isoforms IX and XII, which were recently validated as antitumor drug targets. Moreover, no inhibition of the off-target hCA I and II isoforms was observed. Compounds 8 a–f (another set of triazoles) exhibited nanomolar inhibition against hCA isoforms I, II, IX and XII, among which compounds 8 c, 8 d, and 8 f were found to inhibit the tumor-associated hypoxia-induced hCA isoform IX with Ki values of 1.8, 2.3, and 2.0 nm respectively. Further exploration of these compounds could be useful for the development of novel antitumor agents with selective mechanisms of CA inhibitory action.

HETEROARYL COMPOUNDS AS 5-HT4 RECEPTOR LIGANDS

-

, (2014/07/08)

The present invention relates to novel compounds of formula (I), and their pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their pharmaceutically acceptable salts. The compounds of formula (I) are useful in the treatment of various disorders that are related to 5-HT4 receptors.

HETEROARYL COMPOUNDS AS 5-HT4 RECEPTOR LIGANDS

-

, (2013/04/10)

The present invention relates to novel compounds of formula (I), and their pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their pharmaceutically acceptable salts. The compounds of formula (I) are useful in the treatment of various disorders that are related to 5-HT4 receptors.

Crystalline form of an indazole-carboxamide compound

-

Page/Page column 10, (2008/06/13)

The invention provides crystalline halide salts of 1-isopropyl-1H-indazole-3-carboxylic acid {(1S,3R,5R)-8-[2-(4-acetylpiperazin-1-yl)ethyl]-8-azabicyclo[3.2.1]oct-3-yl}amide and solvates thereof. The invention also provides pharmaceutical compositions comprising such salts, methods of using such crystalline salts to treat diseases associated with 5-HT4 receptor activity, and processes useful for preparing such crystalline salts.

Indazole-carboxamide compounds

-

Page/Page column 23, (2008/06/13)

The invention provides novel indazole-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.

INDAZOLE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS

-

Page/Page column 40-41, (2010/02/13)

The invention provides novel indazole-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.

Development of potent serotonin-3 (5-HT3) receptor antagonists. II. Structure-activity relationships of N-(1-benzyl-4-methylhexahydro-1H-1,4- diazepin-6-yl)carboxamides

Harada,Morie,Hirokawa,Terauchi,Fujiwara,Yoshida,Kato

, p. 1912 - 1930 (2007/10/03)

Our studies on 4-amino-5-chloro-2-ethoxybenzamides led to the discovery that the N-(1,4-dimethylhexahydro-1H-1,4-diazepin-6-yl)benzamide 9 and the 1- benzyl-4-methylhexahydro-1H-1,4-diazepine analogue 10 are potent serotonin-3 (5-HT3) receptor antagonists. Structure-activity relationship (SAR) studies on the influence of the aromatic nucleus of 9 and 10 upon inhibition of the von Bezold-Jarisch reflex in rats are described. Heteroaromatic rings such as pyrrole, thiophene, furan, pyridine, pyridaziae, 1,2-benzisoxazole, indole, quinoline, and isoquinoline rings showed weak 5-HT3 receptor antagonistic activity. Within this series, use of the 1H-indazole ring as an aromatic moiety led to a substantial increase of the activity; the 1H- indazolylcarboxamides 54, 57, 97, and 102 showed potent 5-HT3 receptor antagonistic activity. The optimal compound identified via extensive SAR studies was N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-1H-indazole- 3-carboxamide (54), whose effect was superior to that of the corresponding benzamide 10 and essentially equipotent to those of ondansetron (1) and granisetron (4).

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 173600-05-0