173605-82-8Relevant academic research and scientific papers
Visible-Light-Induced Regioselective Cyanomethylation of Imidazopyridines and Its Application in Drug Synthesis
Chang, Qing,Liu, Zhengyi,Liu, Ping,Yu, Lu,Sun, Peipei
, p. 5391 - 5397 (2017)
3-Cyanomethylated imidazopyridines were synthesized via a visible light-promoted reaction of imidazopyridines with bromoacetonitrile or iodoacetonitrile catalyzed by fac-Ir(ppy)3 under mild conditions. For the substrates with various substituents on benzene or pyridine ring, the reaction proceeded smoothly to give the corresponding products in moderate to good yields. The synthetic utility of this visible-light-induced reaction has been illustrated in the efficient synthesis of zolpidem and alpidem.
Synthesis and antisecretory activity of 6-substituted 5- cyanomethylimidazo[2,1-b]thiazoles and 2,6-dimethyl-5- hydroxymethylimidazo[2,1-b][1,3,4]thiadiazole
Andreani, Aldo,Leoni, Alberto,Locatelli, Alessandra,Morigi, Rita,Rambaldi, Mirella,Simon, Wolfgang A.,Senn-Bilfinger, Joerg
, p. 550 - 553 (2007/10/03)
The synthesis of imidazo[2,1-b]thiazole and imidazo[2,1- b][1,3,4]thiadiazole derivatives, related to known antiulcer agents, is reported. 5-Cyanomethyl-6-methylimidazo[2,1-b]thiazole showed significant antisecretory activity in the isolated rabbit gastri
