1737-21-9

Basic information

• Product Name: Ethyl 2-Hydroxy-4-fluorobenzoate
• Synonyms: Ethyl 2-Hydroxy-4-fluorobenzoate;Ethyl 4-fluoro-2-hydroxybenzoate
• CAS NO: 1737-21-9
• Molecular Formula: C₉H₉FO₃
• Molecular Weight: 184.17
• Product Categories: Esters;Phenyls & Phenyl-Het
• Mol File: 1737-21-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 242.581°C at 760 mmHg
• Flash Point: 100.51°C
• Appearance: /
• Density: 1.257g/cm³
• Vapor Pressure: 0.022mmHg at 25°C
• Refractive Index: 1.52
• Storage Temp.: 2-8°C
• PKA: 8.93±0.10(Predicted)
• CAS DataBase Reference: Ethyl 2-Hydroxy-4-fluorobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-Hydroxy-4-fluorobenzoate(1737-21-9)
• EPA Substance Registry System: Ethyl 2-Hydroxy-4-fluorobenzoate(1737-21-9)

Safety Data

• Hazardous Substances Data: 1737-21-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H9FO3/c1-2-13-9(12)7-4-3-6(10)5-8(7)11/h3-5,11H,2H2,1H3

Upstream product

• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 94-08-6 4-methylbenzoic acid ethyl ester 
• 65-49-6 4-Aminosalicylic acid 
• 345-29-9 4-fluorosalicylic acid 
• 75-03-6 ethyl iodide 
• 64-17-5 ethanol 

Downstream Products

• 149556-92-3 ethyl 4-fluoro-2-hydroxy-5-iodobenzoate 
• 1643-78-3 4-fluoro-N,2-dihydroxybenzamide 
• 1071973-76-6 4-fluoro-2-methoxymethoxy-benzoic acid ethyl ester 
• 167758-90-9 4-fluoro-2-methoxybenzoic acid ethyl ester 

Relevant articles and documents

Design, synthesis and biological evaluation of N-hydroxy-aminobenzyloxyarylamide analogues as novel selective κ opioid receptor antagonists

Aminobenzyloxyarylamide derivatives 1a-i and 2a-t were designed and synthesized as novel selective κ opioid receptor (KOR) antagonists. The benzoyl amide moiety of LY2456302 was changed into N-hydroxybenzamide and benzisoxazole-3(2H)-one to investigate whether it could increase the binding affinity or selectivity for KOR. All target compounds were evaluated in radioligand binding assays for opioid receptor binding affinity. These efforts led to the identification of compound 1c (κ Ki = 179.9 nM), which exhibited high affinity for KOR. Moreover, the selectivity of KOR over MOR and DOR increased nearly 2-fold and 7-fold, respectively, compared with (±)LY2456302.

Ruthenium(II)-catalyzed synthesis of hydroxylated arenes with ester as an effective directing group

An unprecedented Ru(II) catalyzed ortho-hydroxylation has been developed for the facile synthesis of a variety of multifunctionalized arenes from easily accessible ethyl benzoates with ester as an efficient directing group. Both the TFA/TFAA cosolvent system and oxidants serve as the critical success factors in this transformation. The reaction demonstrates excellent reactivity, good functional group tolerance, and high yields.

Compounds containing an amino salicylic acid moiety linked to a sulphapyridine moiety via stable bridge

A compound of the formula Het--NR--SO2 --Ph2 --A--Ph1 (COOH)(OH) and tautomeric form, salts, solvates, C1-6 alkyl esters and pharmaceutical compositions of the compound. Ph1 and Ph2 are ben