17372-87-1 Usage
Chemical Properties
brownish-red powder
Uses
Different sources of media describe the Uses of 17372-87-1 differently. You can refer to the following data:
1. Eosin is most often used as a counterstain to haematoxylin in H&E (haematoxylin and eosin) staining. H&E staining is one of the most commonly used techniques in histology.
2. Anti Septic
3. Eosin Yellowish noted to reduce the affinity of Mg2+-ATPase for ATP and increase the enzyme affinity for Mg2+ at concentrations of 10-50 ?M. At higher concentrations near 100 ?M the affinity for Mg2+-ATPase for the ion-activator has been shown to be reduced. This compound has also been reported to be a photosensitizer that works as a molecular photoelectrode via catalyzation of the visible-light-driven electron-transfer reaction. Eosin Y is also used to stain structures such as muscle, cytoplasm, and collagen. This agent also enhances fluorescent quenching abilities by forming a complex with polyvinulpyrrolidone.
Preparation
countries called red. Fluorescent element (C.I. Acid Yellow 73, C.I. 45350) in water or ethanol solution bromine into four bromine derivatives, and then into sodium salt.
Definition
ChEBI: An organic sodium salt that is 2',4',5',7'-tetrabromofluorescein in which the carboxy group and the phenolic hydroxy group have been deprotonated and the resulting charge is neutralised by two sodium ions.
Flammability and Explosibility
Notclassified
Biological Activity
ami5/eosin y disodium salt is a non-selective protein methyltransferase inhibitor.post-translational protein methylation at lysine and arginine residues is related to the gene expression regulation. the enzymatic activities of protein methyltransferases serve to do covalent modifications in the control of gene transcription.
Safety Profile
Poison by intravenous
and intraperitoneal routes. Moderately toxic
by ingestion. Questionable carcinogen with
experimental tumorigenic data. When heated
to decomposition it emits very toxic fumes
of Brand NazO. See also BROMIDES.
in vitro
ami5/eosin y disodium salt has been identified as a competitive inhibitor of sam binding and had been shown to inhibit not only prmts but also lysine methylation by the set7 and disruptor of telomeric silencing 1-like (dot1l) mtases in vitro. both ami5/eosin y disodium salt and its analog ami-1 have been used as lead compounds for the development of novel mtase-specific inhibitors. moreover, it was found that ami5/eosin y disodium salt could inhibit set7 in vitro and decrease h3k4m1 in vascular endothelial cells. [1].
IC 50
0.78 and 1.41 μm for hmt1p and prmt1, respectively
Properties and Applications
yellow peach. Orange powder, soluble in water and ethanol with fluorescent blue light is yellowish red solution. Meet strong sulfuric acid yellow, it will be diluted yellow light red precipitate generated. Dyeing copper ions in the blue colour and lustre; Iron ion colour and lustre in the dark blue. Discharge the gender is good. Mainly used in red ink and red pencils, only comfortable carpet dyeing. After refining can be used as medicine and cosmetics of coloring. Can also be used in leather dyeing. The aluminum salt can be used as organic pigments.
Standard
Light Fastness
Soaping
Persperation Fastness
Oxygen bleaching
Fastness to seawater
Fading
Stain
Fading
Stain
Fading
Stain
ISO
2
3
3
2
1
2
2
2
AATCC
1
2
2
3
1
1
3
3
Standard
Light Fastness
Fading
Stain
ISO
2
AATCC
1
Purification Methods
Dissolve it in the minimum volume of H2O (1g/mL), filter and add EtOH until separation of salt is complete. Filter the solid off, wash it with absolute EtOH, then Et2O and dry it first in air, then at 100o. It is used for staining blood cells and for estimating traces of Ag. [Selsted & Becker Anal Biochem 155 270 1986, El-Ghamry & Frei Anal Chem 40 1986 1968.] [Beilstein 19 III/IV 2917.] [See above]
references
[1] okabe j,fernandez az,ziemann m,keating st,balcerczyk a,el-osta a. endothelial transcriptome in response to pharmacological methyltransferase inhibition. chemmedchem.2014 aug;9(8):1755-62.
Check Digit Verification of cas no
The CAS Registry Mumber 17372-87-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,3,7 and 2 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 17372-87:
(7*1)+(6*7)+(5*3)+(4*7)+(3*2)+(2*8)+(1*7)=121
121 % 10 = 1
So 17372-87-1 is a valid CAS Registry Number.
InChI:InChI=1/C20H8Br4O5.3Na/c21-11-5-9-13(7-3-1-2-4-8(7)20(27)28)10-6-12(22)17(26)15(24)19(10)29-18(9)14(23)16(11)25;;;/h1-6,25H,(H,27,28);;;/q;3*+1/p-2
17372-87-1Relevant articles and documents
Exponential Amplification Using Photoredox Autocatalysis
Kim, Seunghyeon,Martínez Dibildox, Alejandra,Aguirre-Soto, Alan,Sikes, Hadley D.
, p. 11544 - 11553 (2021)
Exponential molecular amplification such as the polymerase chain reaction is a powerful tool that allows ultrasensitive biodetection. Here, we report a new exponential amplification strategy based on photoredox autocatalysis, where eosin Y, a photocatalyst, amplifies itself by activating a nonfluorescent eosin Y derivative (EYH3-) under green light. The deactivated photocatalyst is stable and rapidly activated under low-intensity light, making the eosin Y amplification suitable for resource-limited settings. Through steady-state kinetic studies and reaction modeling, we found that EYH3- is either oxidized to eosin Y via one-electron oxidation by triplet eosin Y and subsequent 1e-/H+ transfer, or activated by singlet oxygen with the risk of degradation. By reducing the rate of the EYH3- degradation, we successfully improved EYH3-to-eosin Y recovery, achieving efficient autocatalytic eosin Y amplification. Additionally, to demonstrate its flexibility in output signals, we coupled the eosin Y amplification with photoinduced chromogenic polymerization, enabling sensitive visual detection of analytes. Finally, we applied the exponential amplification methods in developing bioassays for detection of biomarkers including SARS-CoV-2 nucleocapsid protein, an antigen used in the diagnosis of COVID-19.
Metalocarboxypeptidase inhibitors and derived molecules used as antitumor agents
-
, (2008/06/13)
The present invention relates to metalocarboxypeptidase inhibitors and to their natural protein variants or protein variants redesigned by engineering, as well as to peptidomimetic molecules derived from the above and used as antitumor agents.
Phototoxic insecticidal composition and method for controlling insect populations
-
, (2008/06/13)
A phototoxic insecticidal composition includes at least one photoactive dye present in the amount of between 0.025%-4.0% of the composition, an attractant compound and/or feeding stimulant and at least one adjuvant, whereby the adjuvant interacts with the photoactive dye and insect membranes to alter the toxicity of the composition once ingested by the insect.
