1739-10-2Relevant articles and documents
Ureate Titanium Catalysts for Hydroaminoalkylation: Using Ligand Design to Increase Reactivity and Utility
Man?en, Manfred,Deng, Danfeng,Zheng, Cameron H. M.,Dipucchio, Rebecca C.,Chen, Dafa,Schafer, Laurel L.
, p. 4550 - 4560 (2021/05/04)
Hydroaminoalkylation describes the atom-economical catalytic synthesis of amines by forming new Csp3-Csp3 bonds using readily available amine and alkene feedstocks. Herein, we describe an earth-abundant and cost-efficient titanium catalyst generated in si
Manganese-Catalyzed Hydroarylation of Unactivated Alkenes
Liu, Ting,Wang, Congyang,Yang, Yunhui
supporting information, p. 14256 - 14260 (2020/07/13)
Transition-metal-catalyzed hydroarylation of unactivated alkenes with strategic use of remote coordinating functional groups has received significant attention recently to address the issues of both low reactivity and poor selectivity. The bidentate 8-aminoquinoline amide group is the most successfully adopted in unactivated alkenes for Pd and Ni catalysis. We describe the first manganese-catalyzed hydroarylation of unactivated alkenes bearing diverse simple functionalities with arylboronic acids. A series of δ- and γ-arylated amides, ketones, pyridines, and amines was accessed with excellent regioselectivity and in high yields. Hydroalkenylation of unactivated alkenes was also shown to be applicable under this manganese-catalysis regime. The method features earth-abundant manganese catalysis, easily available substrates, broad functional-group tolerance, and excellent regioselective control.
Dehydroxylation of alcohols for nucleophilic substitution
Chen, Jia,Lin, Jin-Hong,Xiao, Ji-Chang
, p. 7034 - 7037 (2018/07/05)
The Ph3P/ICH2CH2I system-promoted dehydroxylative substitution of alcohols was achieved to construct C-O, C-N, C-S and C-X (X = Cl, Br, and I) bonds. Compared with the previous approaches such as the Appel reaction and Mitsunobu reaction, this protocol offers some practical advantages such as safe operation and a convenient amination process.