173918-46-2

Upstream product

• 141483-49-0 N,N-dibenzyl-glycine benzyl ester 
• 106889-84-3 2-N,N-Dibenzylaminoacetaldehyde 
• 101-06-4 N,N-dibenzyl-2-aminoethanol 
• 1206893-55-1 diethyl 2-(N,N-dibenzylamino)-1-hydroxyethanephosphonate 
• 65130-83-8 N-benzyl-N-methylene-1-phenylmethanaminium chloride 
• 65094-25-9 diethyl dibromofluoromethylphosphonate 
• 58288-30-5 N,N,N′,N′-tetrabenzylmethanediamine 

Relevant academic research and scientific papers

Synthesis of monofluoro- and difluoro- methylenephosphonate analogues of sn-glycerol-3-phosphate as substrates for glycerol-3-phosphate dehydrogenase and the X-ray structure of the fluoromethylenephosphonate moiety

The synthesis of the cyclohexylammonium salts of (1RS, 3S)-3,4-dihydroxy-1-fluorobutylphosphonic acid 3 and (S)-difluoro-3,4-dihydroxybutylphosphonic acid 4 is reported. These compounds are fluorinated phosphonate analogues of sn-glycerol-3-phosphate wher

DAST mediated preparation of β-fluoro-α-aminophosphonates

Herein, we report a new and convenient method for the synthesis of β-fluoro-α-aminophosphonates starting from naturally occurring l-amino acids. A key step in the synthetic protocol involves nucleophilic fluorination of N,N-dibenzylated-β-amino alcohols with diethylaminosulfur trifluoride (DAST).