173952-44-8 Usage
Uses
SYM 2206 is a potent, selective and noncompetitive AMPA receptor inhibitor.
Biological Activity
Novel, potent, non-competitive AMPA receptor antagonist (IC 50 = 2.8 μ M ). Acts allosterically at the same regulatory site as GYKI 52466 and 53655 and other benzodiazepines but does not bind to the central diazepine binding site. Selective for AMPA relative to kainate receptor sub-types. Similar potency to GYKI 53655. Anticonvulsant in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 173952-44-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,3,9,5 and 2 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 173952-44:
(8*1)+(7*7)+(6*3)+(5*9)+(4*5)+(3*2)+(2*4)+(1*4)=158
158 % 10 = 8
So 173952-44-8 is a valid CAS Registry Number.
InChI:InChI=1/C20H22N4O3/c1-3-8-22-20(25)24-12(2)15-9-17-18(27-11-26-17)10-16(15)19(23-24)13-4-6-14(21)7-5-13/h4-7,9-10,12H,3,8,11,21H2,1-2H3,(H,22,25)
173952-44-8Relevant articles and documents
Dihydrophthalazine antagonists of excitatory amino acid receptors
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, (2008/06/13)
Substituted dihydrophthalazine compositions are provided which are active as non-NMDA ionotropic excitatory amino acid (EAA) receptor antagonists. The compositions are useful for treating disorders associated with excessive activation of the non-NMDA subt
