17396-68-8Relevant academic research and scientific papers
Aminochlorination of Alkenes with CFBSA
Pu, Xiao-Qiu,Zhao, Hai-Yong,Lu, Ze-Hai,He, Xiao-Peng,Yang, Xian-Jin
, p. 4526 - 4533 (2016)
A novel catalyst-free aminochlorination of alkenes was developed by the direct addition of alkenes to N-chloro-N-fluorobenzenesulfonamide (CFBSA). The reaction produces 2-chloro-3-fluoramino and 3-chloro-2-fluoroamino adducts in 1,2-dichloroethane under reflux and dichloromethane at room temperature, respectively, in a regioselective manner. The electronic and steric effects of the fluorine atom of CFBSA have proven to be crucial for the reactivity and regioselectivity. A variety of transformations have been achieved to form 2-chloroenamines, chloroamines, aziridines and N-phenylbenzenesulfonamides under different conditions. Notably, the N–F bond in the adducts formed could be a useful handle for further transformations to useful compounds in organic synthesis.
Copper-catalyzed intermolecular aminochlorination of alkenes
Arteaga, Gean C.,Saavedra-Olavarría, Jorge,Almendras, Sebastián,Hermosilla-Ibá?ez, Patricio,Almodovar, Iriux,Pérez, Edwin G.
, p. 1091 - 1093 (2018)
A copper-catalyzed radical and regioselective aminochlorination of alkenes using N-fluoro-benzenesulfonimide (NFSI) and TMSCl as nitrogen and chlorine sources respectively is reported.
