173974-89-5

Upstream product

• 118460-39-2 ethyl 2,2-difluoro-3-hydroxy-5-phenylpentanoate 
• 6160-65-2 1,1'-Thiocarbonyldiimidazole 

Downstream Products

• 155324-33-7 (2'R,3'S,4S)-3-(4',4'-difluoro-3'-hydroxy-2'-methyl-7'-phenylheptanoyl)-4-isopropyl-2-oxazolidinone 
• 155324-34-8 (2'S,3'S,4S)-3-(4',4'-difluoro-3'-hydroxy-2'-methyl-7-phenylheptanoyl)-4-isopropyl-2-oxazolidinone 
• 155245-89-9 (2'R,3'R,4S)-3-(4',4'-difluoro-3'-hydroxy-2'-methyl-7-phenylheptanoyl)-4-isopropyl-2-oxazolidinone 
• 128483-83-0 2,2-difluoro-5-phenylpentanal 
• 128483-82-9 ethyl 2,2-difluoro-5-phenylpentanoate 

Relevant academic research and scientific papers

Reversal of stereoselectivity in the Evans aldol reaction of α,α-difluoro and α,α,α-trifluoro carbonyl compounds

The Evans aldol reaction of hexafluoroacetone and trifluoroacetaldehyde causes complete reversal of diastereofacial selectivity. The boron enolate derived from N-acyloxazolidinone 2 reacts with trifluoroacetaldehyde to give anti and "non-Evans" syn aldols