1740-63-2Relevant academic research and scientific papers
PALLADIUM-CATALYZED ASYMMETRIC CYCLIZATION OF METHYL (E)-OXO-9-PHENOXY-7-NONENOATE AND ITS ANALOGS
Yamamoto, Keiji,Tsuji, Jiro
, p. 3089 - 3092 (1982)
Asymmetric cyclizations of methyl (E)-3-oxo-9-phenoxy-7-nonenoate (1) or methyl (E)-3-oxo-9-(methoxycarbonyl)oxy-7-nonenoate (4) without added base were carried out in the presence of a catalytic amount of palladium(II) acetate and chiral diphosphine as l
Construction of AE ring system for the C19-diterpenoid alkaloids with a 5β-hydroxyl group
Yang, Zhan-Kun,Chen, Qiao-Hong,Wang, Feng-Peng
, p. 4192 - 4195 (2011)
An AE azabicyclic fragment, with a β-hydroxyl group at C-5 and a substituent at C-1, of the C19-diterpenoid alkaloids, was synthesized. The key reactions include an intramolecular Claisen-type condensation, double Mannich reaction, and stereose
COMPLETE RETENTION OF CHIRALITY IN THE PALLADIUM CATALYZED CYCLIZATION OF METHYL (R)-3-OXO-7-METHOXYCARBONYLOXY)-8-NONENOATE
Yamamoto, Keiji,Deguchi, Ryoji,Ogimura, Yoshinobu,Tsuji, Jiro
, p. 1657 - 1660 (1984)
Optically active methyl (R)-3-oxo-7-methoxycarbonyloxy)-8-nonenoate (1) underwent intramolecular allylation catalyzed by Pd(OAc)2-dppe in THF at room temperature to give racemic 3-vinyl-2-methoxy-carbonylcyclohexanone (3), whereas similar palladium-cataly
Synthesis and Structure-Activity Relationship Studies of Anti-Inflammatory Epoxyisoprostane Analogues
Wolleb, Helene,Ogawa, Seiji,Schneider, Michael,Shemet, Andrej,Muri, Jonathan,Kopf, Manfred,Carreira, Erick M.
supporting information, p. 3014 - 3016 (2018/05/28)
The lactone derivative of the epoxyisoprostane EC is a highly effective inhibitor of the secretion of the proinflammatory cytokine IL-6. Herein, a modular synthesis of analogues is described, allowing flexible variations of the cyclic side chain of the parent lactone. A structure-activity relationship study identified a lactam analogue that retains the high activity. Furthermore, the exocyclic allylic alcohol was shown to be crucial for the observed effect.
Observations on the reductive ring opening reactions of alkylidenecyclopropyl ketones promoted by lithium in liquid ammonia
Motherwell, William B.,Zuberi, Sheena
, p. 8789 - 8791 (2007/10/03)
The regio- and stereochemical outcome of the reductive ring opening reactions of alkylidenecyclopropyl ketones is a function of substrate structure.
Potassium organotrifluoroborates in rhodium-catalyzed asymmetric 1,4-additions to enones
Pucheault, Mathieu,Darses, Sylvain,Genet, Jean-Pierre
, p. 3552 - 3557 (2007/10/03)
Potassium organotrifluoroborates, highly stable organoboron derivatives, participate in asymmetric 1,4-additions to enones. This reaction, catalyzed by cationic rhodium(I) complexes chelated with binap, MeO-biphep or josiphos ligand, affords 1,4-adducts w
Quasi-nature catalysis: Conjugated addition of unsaturated carbonyl compounds with aryl and vinyltin reagents catalyzed by rhodium in air and water
Venkatraman, Sripathy,Meng, Yue,Li, Chao-Jun
, p. 4459 - 4462 (2007/10/03)
In air and water, trialkylphenyl- or trialkylvinylstannanes react with α,β-unsaturated esters and ketones to give the corresponding conjugated addition products in high yields in the presence of a rhodium catalyst.
Beryllium dichloride: Efficient promoter for the addition of organolithiums and organomagnesiums to cyclohexen-2-one
Krief, Alain,De Vos, Marie Joelle,De Lombart, Stephane,Bosret, Jean,Couty, Francois
, p. 6295 - 6298 (2007/10/03)
Organoberyllium compounds, generated by transmetallation from Grignard and organolithium reagents react with 2-cyclohexenone to give predominantly the adducts resulting from conjugated addition. The chemoselectivity of this reaction was found to be highly dependent upon the nature of organic moiety and of the conditions used.
Intramolecular cyclisations of hydroxylamines derived from limonene: Reverse-Cope or acid-catalysed reactions?
Coogan, Michael P.,Knight, David W.
, p. 6417 - 6420 (2007/10/03)
Intramolecular cyclisations of cis-4-ethenylcyclohexyl hydroxylamines [e.g. 3 derived from limonene] proceed via a reverse-Cope mechanism rather than an acid-catalysed process, as recently reported.
Metal-Catalyzed Organic Photoreactions. Chemo- and Regioselectivities in the CuCl2-Induced Photooxidation of Olefins.
Sato, Tadashi,Yonemochi, Shin-ichi
, p. 7375 - 7384 (2007/10/02)
Copper(II) chloride induced the chemo and regioselective chlorohydroperoxidation, as well as the site-selective chlorination of olefins, under photooxygenation conditions.
