1740-63-2Relevant articles and documents
Corey,Beames
, p. 7210 (1972)
Construction of AE ring system for the C19-diterpenoid alkaloids with a 5β-hydroxyl group
Yang, Zhan-Kun,Chen, Qiao-Hong,Wang, Feng-Peng
, p. 4192 - 4195 (2011)
An AE azabicyclic fragment, with a β-hydroxyl group at C-5 and a substituent at C-1, of the C19-diterpenoid alkaloids, was synthesized. The key reactions include an intramolecular Claisen-type condensation, double Mannich reaction, and stereose
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Dowd et al.
, p. 5725 (1970)
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Synthesis and Structure-Activity Relationship Studies of Anti-Inflammatory Epoxyisoprostane Analogues
Wolleb, Helene,Ogawa, Seiji,Schneider, Michael,Shemet, Andrej,Muri, Jonathan,Kopf, Manfred,Carreira, Erick M.
supporting information, p. 3014 - 3016 (2018/05/28)
The lactone derivative of the epoxyisoprostane EC is a highly effective inhibitor of the secretion of the proinflammatory cytokine IL-6. Herein, a modular synthesis of analogues is described, allowing flexible variations of the cyclic side chain of the parent lactone. A structure-activity relationship study identified a lactam analogue that retains the high activity. Furthermore, the exocyclic allylic alcohol was shown to be crucial for the observed effect.
Potassium organotrifluoroborates in rhodium-catalyzed asymmetric 1,4-additions to enones
Pucheault, Mathieu,Darses, Sylvain,Genet, Jean-Pierre
, p. 3552 - 3557 (2007/10/03)
Potassium organotrifluoroborates, highly stable organoboron derivatives, participate in asymmetric 1,4-additions to enones. This reaction, catalyzed by cationic rhodium(I) complexes chelated with binap, MeO-biphep or josiphos ligand, affords 1,4-adducts w
