174309-35-4

Basic information

• Product Name: Benzenemethanol, -alpha--(1-amino-2-propenyl)- (9CI)
• Synonyms: Benzenemethanol, -alpha--(1-amino-2-propenyl)- (9CI)
• CAS NO: 174309-35-4
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.22
• Mol File: 174309-35-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenemethanol, -alpha--(1-amino-2-propenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, -alpha--(1-amino-2-propenyl)- (9CI)(174309-35-4)
• EPA Substance Registry System: Benzenemethanol, -alpha--(1-amino-2-propenyl)- (9CI)(174309-35-4)

Safety Data

• Hazardous Substances Data: 174309-35-4(Hazardous Substances Data)

Upstream product

• 20248-57-1 2-phenyl-3-vinyloxirane 
• 100-52-7 benzaldehyde 
• 25438-37-3 phenyl(trimethylsiloxy)acetonitrile 
• 1826-67-1 vinyl magnesium bromide 
• 120235-56-5 2-(Benzhydrylidene-amino)-1-phenyl-but-3-en-1-ol 

Downstream Products

• 174309-37-6 Acetic acid 2-acetylamino-1-phenyl-but-3-enyl ester 
• 4411-89-6 (E/Z)-2-phenylcrotonaldehyde 
• 81135-75-3 2-Acetylamino-3-hydroxy-3-phenyl-propionic acid methyl ester 
• 3313-19-7 (1RS,2SR)-2-acetylamino-1-phenyl-propane-1,3-diol 

Relevant articles and documents

Stereoselective Synthesis of (1R,2S)-2-Amino-1,3-diols from (R)-Cyanohydrins

Vinyl substituted (1R,2S)-amino alcohols 5 were obtained by addition of vinyl magnesium bromide to the corresponding cyanohydrin O-trimethylsilyl ethers (R)-2.The O- and N-protected vinyl amino alcohols 6 were ozonized at -78 deg C in methanol yielding (1R,2S)-2-amino-1,3-diols 7 in high enantiomeric and diastereomeric excesses.For purification, compounds 7 in some cases were acetylated to give the derivatives (1R,2S)-8.Racemic 6a was converted by oxidative ozonolysis at -78 deg C in methanolic NaOH solution to the corresponding methyl N-acetyl-β-hydroxy propanoate 9a.The configuration of (1R,2S)-8a was confirmed by x-ray crystallographic analysis.