3313-19-7

Upstream product

• 3306-06-7 (+/-)-threo-2-amino-1-phenyl-1,3-propanediol 
• 108-24-7 acetic anhydride 
• 99986-50-2 (2RS,3RS)-3-acetoxy-2-amino-3-phenyl-propan-1-ol; hydrochloride 
• 100610-56-8 (1RS,2RS)-1,3-diacetoxy-2-amino-1-phenyl-propane; hydrochloride 
• 3306-06-7 (1RS,2SR)-2-amino-1-phenyl-propane-1,3-diol 
• 99986-50-2 (2RS,3SR)-3-acetoxy-2-amino-3-phenyl-propan-1-ol; hydrochloride 
• 75-36-5 acetyl chloride 
• 868659-35-2 (+/-)-2-[(tert-butyldimethylsilyloxy)(phenyl)methyl]-2-prop-2-en-1-ol 
• 164853-29-6 (±)-methyl 2-{[(tert-butyldimethylsilyl)oxy](phenyl)methyl}prop-2-enoate 
• 1375105-52-4 C₁₈H₂₈O₃Si 
• 3509-71-5 α-Oximino-β,β-dimethoxy-propiophenon 
• 1846-33-9 N-phenacylacetamide 
• 174309-35-4 2-amino-1-phenyl-but-3-en-1-ol 
• 25438-37-3 phenyl(trimethylsiloxy)acetonitrile 

Downstream Products

• 3532-60-3 N-((1RS,2RS)-2-methoxy-1-methoxymethyl-2-phenyl-ethyl)-acetamide 
• 3509-75-9 (1RS,2SR)-1,3-diacetoxy-2-acetylamino-1-phenyl-propane 
• 3306-06-7 (+/-)-threo-2-amino-1-phenyl-1,3-propanediol 
• 129217-19-2 4(R*)-<(S*)-hydroxy(phenyl)methyl>-1,3-oxazolin-2-one 
• 33485-02-8 (1RS,2SR)-1,3-diacetoxy-2-acetylamino-1-(4-nitro-phenyl)-propane 
• 56-75-7 2-(2,2-dichloroacetylamino)-1-(4-nitrophenyl)propane-1,3-diol 
• 1885-08-1 (1RS,2RS)-2-acetylamino-1-(4-nitro-phenyl)-propane-1,3-diol 
• 119-62-0 (1RS,2SR)-2-amino-1-(4-nitro-phenyl)-propane-1,3-diol 
• 53732-41-5 (+/-)-(2-methyl-5t-phenyl-4,5-dihydro-oxazol-4r-yl)-methanol 
• 3532-61-4 N-[(1RS,2RS)-2-methoxy-1-methoxymethyl-2-(4-nitro-phenyl)-ethyl]-acetamide 
• 99982-62-4 (1S,2S)-2-methoxy-1-methoxymethyl-2-(4-nitro-phenyl)-ethylamine 
• 99986-50-2 (2RS,3RS)-3-acetoxy-2-amino-3-phenyl-propan-1-ol; hydrochloride 
• 110461-00-2 N-[4c-(4-nitro-phenyl)-2ξ-oxo-2λ⁴-[1,3,2]dioxathian-5r-yl]-acetamide 

Relevant academic research and scientific papers

Diastereoselective synthesis of substituted 2-Amino-1,3-propanediols from morita Baylis-Hillman adducts

We report herein a new diastereoselective approach to substituted 2-amino-1,3-propanediols with anti relative stereochemistry from Morita-Baylis-Hillman (MBH) adducts. These structural moieties have been used as intermediates for the synthesis of several

Stereoselective Synthesis of (1R,2S)-2-Amino-1,3-diols from (R)-Cyanohydrins

Vinyl substituted (1R,2S)-amino alcohols 5 were obtained by addition of vinyl magnesium bromide to the corresponding cyanohydrin O-trimethylsilyl ethers (R)-2.The O- and N-protected vinyl amino alcohols 6 were ozonized at -78 deg C in methanol yielding (1R,2S)-2-amino-1,3-diols 7 in high enantiomeric and diastereomeric excesses.For purification, compounds 7 in some cases were acetylated to give the derivatives (1R,2S)-8.Racemic 6a was converted by oxidative ozonolysis at -78 deg C in methanolic NaOH solution to the corresponding methyl N-acetyl-β-hydroxy propanoate 9a.The configuration of (1R,2S)-8a was confirmed by x-ray crystallographic analysis.