174456-77-0

Basic information

• Product Name: Ethyl 3-azabicyclo[3.1.0]hexane-6-carboxylate
• Synonyms: ETHYL 3-AZABICYCLO[3.1.0]HEXANE-6-CARBOXYLATE;3-Azabicyclo[3.1.0]hexane-6-carboxylicacid,ethylester,(1alpha,5alpha,6alpha)-(9CI);cis-Ethyl 3-azabicyclo[3.1.0]hexane-6-carboxylate;Ethyl cis-3-azabicyclo[3.1.0]hexane-6-carboxylate;ethyl (1R*,5S*,6r*)-3-azabicyclo[3.1.0]hexane-6-carboxylate(SALTDATA: HCl);(1R,5S)-Ethyl 3-azabicyclo[3.1.0]hexane-6-carboxylate;(1R,5S,6r)-rel-Ethyl 3-azabicyclo[3.1.0]hexane-6-carboxylate;(1R,5S,6r)-ethyl 3-azabicyclo[3.1.0]hexane-6-carboxylate
• CAS NO: 174456-77-0
• Molecular Formula: C₈H₁₃NO₂
• Molecular Weight: 155.19
• Product Categories: CARBOXYLICESTER;pharmacetical
• Mol File: 174456-77-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 212.6oC at760mmHg
• Flash Point: 82.4oC
• Appearance: /
• Density: 1.127g/cm³
• Vapor Pressure: 0.172mmHg at 25°C
• Refractive Index: 1.493
• PKA: 10.49±0.40(Predicted)
• CAS DataBase Reference: Ethyl 3-azabicyclo[3.1.0]hexane-6-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 3-azabicyclo[3.1.0]hexane-6-carboxylate(174456-77-0)
• EPA Substance Registry System: Ethyl 3-azabicyclo[3.1.0]hexane-6-carboxylate(174456-77-0)

Safety Data

• Hazardous Substances Data: 174456-77-0(Hazardous Substances Data)

Usage

General Description

Ethyl 3-azabicyclo[3.1.0]hexane-6-carboxylate is a chemical compound with a unique and complex structure. It is a derivative of the azabicyclo[3.1.0]hexane ring system and contains an ethyl ester functional group. Ethyl 3-azabicyclo[3.1.0]hexane-6-carboxylate has potential applications in medicinal chemistry as a building block for the synthesis of pharmaceuticals and bioactive compounds. Its stable and rigid structure makes it an interesting target for chemical synthesis and structural modification. Overall, Ethyl 3-azabicyclo[3.1.0]hexane-6-carboxylate is a versatile and valuable chemical compound with various potential uses in the field of chemistry and pharmacology.

InChI:InChI=1/C8H13NO2/c1-2-11-8(10)7-5-3-9-4-6(5)7/h5-7,9H,2-4H2,1H3

Upstream product

• 146726-10-5 3-benzyl 6-ethyl (1α,5α,6α)-3-azabicyclo[3.1.0]hexane-3,6-dicarboxylate 
• 134575-06-7 ethyl (1α,5α,6α)-3-benzyl-3-azabicyclo[3.1.0]hexane-2,4-dione-6-carboxylate 

Downstream Products

• 681424-94-2 exo-(1R,5S)-3-(2,6-difluoro-4-nitro-phenyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid ethyl ester 
• 134575-15-8 (1α,5α,6α)-3-(benzyloxycarbonyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid 
• 146726-08-1 (1α,5α,6α)-6-tert-butoxycarbonylamino-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid benzyl ester 
• 134575-17-0 tert-butyl (1R,5S,6R)-3-azabicyclo[3.1.0]hexan-6-ylcarbamate 

Relevant articles and documents

Synthesis and diacylglycerol acyltransferase-1 inhibition of azabicyclo[3.1.0]hexane derivatives

We identified azabicyclo[3.1.0]hexane derivatives that are active diacylglycerol acyltransferase-1 (DGAT)-1 inhibitor. Among the azabicyclo[3.1.0]hexane series, compound 6b showed good in vitro activity toward human DGAT-1, selectivity toward DGAT-2, and

BENZODIOXANE INHIBITORS OF LEUKOTRIENE PRODUCTION FOR COMBINATION THERAPY

The present invention relates to a combination comprising compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein, and an additional active agent. The present invention also relates to pharmaceutical compositions comprising these combinations, and methods of using these combinations to treat various diseases and disorders.

SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANE DERIVATIVES USEFUL AS CCR2 ANTAGONISTS

Disclosed are CCR2 antagonists of Formula (I)or pharmaceutically acceptable thereof, wherein R1, L1 and A are defined herein. Also disclosed are pharmaceutical compositions containing the compounds, methods of treatment using the compounds, and compositions to treat diseases or disorders associated with CCR2 activity.