134575-15-8

Basic information

• Product Name: exo-3-Cbz-3-azabicyclo[3.1.0]hexane-6-carboxylic acid
• Synonyms: exo-3-Cbz-3-azabicyclo[3.1.0]hexane-6-carboxylic acid;(1S,5R)-3-Benzyloxycarbonyl-3-azabicyclo[3.1.0]hexan-6-carboxylic acid;(1S,5R)-3-Benzyloxycarbonyl-3-azabicyclo[3.1.0]hexane-6-carboxylic acid;exo-3-((Benzyloxy)carbonyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid;(1alpha,5alpha,6alpha)-3-(benzyloxycarbonyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid
• CAS NO: 134575-15-8
• Molecular Formula: C₁₄H₁₅NO₄
• Molecular Weight: 261.2732
• Mol File: 134575-15-8.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: exo-3-Cbz-3-azabicyclo[3.1.0]hexane-6-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: exo-3-Cbz-3-azabicyclo[3.1.0]hexane-6-carboxylic acid(134575-15-8)
• EPA Substance Registry System: exo-3-Cbz-3-azabicyclo[3.1.0]hexane-6-carboxylic acid(134575-15-8)

Safety Data

• Hazardous Substances Data: 134575-15-8(Hazardous Substances Data)

Usage

General Description

Exo-3-Cbz-3-azabicyclo[3.1.0]hexane-6-carboxylic acid is a chemical compound with a complex structure, consisting of a bicyclic ring system and a carboxylic acid functional group. The "exo-3" prefix indicates the location of the substituent on the bridged ring, and the "Cbz" group is a protective chemical group often used in organic synthesis. exo-3-Cbz-3-azabicyclo[3.1.0]hexane-6-carboxylic acid has potential applications in medicinal chemistry and drug development, as the unique structure may confer specific biological activities or properties. Research on this compound may focus on its synthesis, characterization, and potential pharmacological uses.

Upstream product

• 146726-10-5 3-benzyl 6-ethyl (1α,5α,6α)-3-azabicyclo[3.1.0]hexane-3,6-dicarboxylate 
• 75-09-2 dichloromethane 
• 479672-17-8 (E)-methyl 4-(((benzyloxy)carbonyl)amino)but-2-enoate 
• 5041-33-8 N-(Benzyloxycarbonyl)allylamine 
• 174456-77-0 [(1α,5α,6α)-3-aza-bicyclo[3.1.0]hexane]-6-carboxylic acid ethyl ester 
• 134575-06-7 ethyl (1α,5α,6α)-3-benzyl-3-azabicyclo[3.1.0]hexane-2,4-dione-6-carboxylate 
• 134575-07-8 (1α,5α,6α)-6-hydroxymethyl-3-benzyl-3-aza-bicyclo[3.1.0]hexane 
• 134575-13-6 (1α,5α,6α)-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane 
• 31970-04-4 1-carboxybenzyl-3-pyrrolidine 
• 134575-14-7 benzyl (1α,5α,6α)-6-hydroxymethyl-3-azabicyclo[3.1.0]hexan-3-ylcarboxylate 

Downstream Products

• 146726-08-1 (1α,5α,6α)-6-tert-butoxycarbonylamino-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid benzyl ester 
• 134575-14-7 benzyl (1α,5α,6α)-6-hydroxymethyl-3-azabicyclo[3.1.0]hexan-3-ylcarboxylate 
• 925457-08-5 1-(2,4-difluorophenyl)-7-[(1α,5α,6α)-6-[[(1,1-dimethylethoxy)carbonyl]amino]-3-azabicyclo[3.1.0]hex-3-yl]-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid 
• 134575-17-0 tert-butyl (1R,5S,6R)-3-azabicyclo[3.1.0]hexan-6-ylcarbamate 

Relevant articles and documents

Efficient synthesis of cyclopropane-fused heterocycles with bromoethylsulfonium salt

Lord of the rings! [3.1.0] bicyclic ring systems were synthesized using bromoethylsulfonium triflate and easily available amino acid/aza-Morita-Baylis- Hillman-derived allylic amines. The simple transformation displays a very high degree of diastereoselec

SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANE DERIVATIVES USEFUL AS CCR2 ANTAGONISTS

Disclosed are CCR2 antagonists of Formula (I)or pharmaceutically acceptable thereof, wherein R1, L1 and A are defined herein. Also disclosed are pharmaceutical compositions containing the compounds, methods of treatment using the compounds, and compositions to treat diseases or disorders associated with CCR2 activity.

Conformational constraint in oxazolidinone antibacterials. Synthesis and structure-activity studies of (azabicyclo[3.1.0]hexylphenyl)oxazolidinones

The oxazolidinones are a new class of synthetic antibacterials effective against a broad range of pathogenic Gram-positive bacteria, including multi-drug-resistant strains. Linezolid is the first drug from this class to reach the market and has become an