134575-06-7

Basic information

• Product Name: CIVENTICHEM CV-4328
• Synonyms: Ethyl 3-benzyl-2,4-dioxo-3-aza-bicyclo[3.1.0]hexane-6-carboxylate;ethyl trans-3-benzyl-2,4-dioxo-3-aza-bicyclo[3.1.0]hexane-6-carboxylate;ethyl (1α,5α,6α)-3-benzyl-3-azabicyclo[3.1.0]hexane-2,4-dione-6-carboxylate;ethyl(1R,5S,6r)-3-benzyl-2,4-dioxo-3-azabicyclo[3.1.0]hexane-6-carboxylate;CIVENTICHEM CV-4328;Ethyl 3-benzyl-2,4-dioxo-...
• CAS NO: 134575-06-7
• Molecular Formula: C₁₅H₁₅NO₄
• Molecular Weight: 245.32
• Mol File: 134575-06-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 99～100℃
• Boiling Point: 467.3°C at 760 mmHg
• Flash Point: 236.4°C
• Appearance: /
• Density: 1.339g/cm³
• Vapor Pressure: 6.59E-09mmHg at 25°C
• Refractive Index: 1.599
• PKA: -2.40±0.40(Predicted)
• CAS DataBase Reference: CIVENTICHEM CV-4328(CAS DataBase Reference)
• NIST Chemistry Reference: CIVENTICHEM CV-4328(134575-06-7)
• EPA Substance Registry System: CIVENTICHEM CV-4328(134575-06-7)

Safety Data

• Hazardous Substances Data: 134575-06-7(Hazardous Substances Data)

Usage

General Description

CIVENTICHEM CV-4328 is a specific chemical compound that falls under the category of specialty chemicals. It is primarily used as a surfactant and wetting agent in various industrial applications, including in the production of detergents, cleaning products, and agricultural formulations. CIVENTICHEM CV-4328 is known for its ability to lower the surface tension of liquids, allowing for improved spreading and absorption of substances. CIVENTICHEM CV-4328 is also valued for its emulsifying properties, making it useful in the formulation of emulsions and suspensions. Additionally, it is often used as a dispersing agent to help maintain the stability and uniformity of solutions. Overall, CIVENTICHEM CV-4328 plays a critical role in enhancing the performance and effectiveness of a wide range of products and processes in various industries.

InChI:InChI=1/C15H15NO4/c1-2-20-15(19)12-10-11(12)14(18)16(13(10)17)8-9-6-4-3-5-7-9/h3-7,10-12H,2,8H2,1H3

Upstream product

• 846024-42-8 3-benzyl-2,4-dioxo-3-azabicyclo[3.1.0]hexane-6-carboxylic acid ethyl ester 
• 13949-99-0 trans,meso-cyclopropanetricarboxylic acid triethyl ester 
• 705-35-1 trans,meso-1,2,3-cyclopropanetricarboxylic acid 
• 1631-26-1 1-benzyl-1H-pyrrole-2,5-dione 
• 134575-05-6 ethyl 5-benzyl-4,6-dioxo-1,3a,4,5,6,6a-hexahydropyrrolo[3,4-c]pyrazole-3-carboxylate 
• 64-17-5 ethanol 
• 1366657-90-0 (1R,5S,6r)-3-benzyl-2,4-dioxo-3-azabicyclo[3.1.0]hexane-6-carboxylic acid 
• 187681-87-4 (1R,5S,6s)-2,4-dioxo-3-oxabicyclo[3.1.0]hexane-6-carboxylic acid 
• 7380-81-6 ethyl (dimethylsulfuranylidene)acetate 
• 623-73-4 diazoacetic acid ethyl ester 

Downstream Products

• 1173177-20-2 C₁₈H₂₄ClFN₂O₂ 
• 1173177-23-5 C₂₃H₂₈ClFN₄O₃ 
• 1173239-42-3 1-methyl-1H-imidazole-4-carboxylic acid (3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-chloro-4-fluoro-benzyl)-amide 
• 419572-18-2 (1R,5S,6r)-tert-butyl 6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate 
• 1173239-39-8 1-methyl-1H-imidazole-4-carboxylic acid (3-chloro-4-fluoro-benzyl)-(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide 
• 927679-54-7 (1α,5α,6α)-3-(tert-butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid 
• 1330003-88-7 1-(3-chloro-4-fluorophenyl)-N-{[(1R,5S,6s)-3-methyl-3-azabicyclo[3.1.0]hex-6-yl](2H₁)methyl}(13C,2H₂)methan(15N)amine 
• 146726-10-5 3-benzyl 6-ethyl (1α,5α,6α)-3-azabicyclo[3.1.0]hexane-3,6-dicarboxylate 
• 174456-77-0 [(1α,5α,6α)-3-aza-bicyclo[3.1.0]hexane]-6-carboxylic acid ethyl ester 
• 1400657-53-5 C₁₂H₁₉NO₂ 
• 1400657-52-4 C₁₄H₂₃NO₂ 
• 1400657-51-3 C₂₁H₂₇F₃N₂O*ClH 
• 1400656-32-7 C₂₁H₂₇F₃N₂O 
• 1400657-50-2 C₁₅H₁₇F₃N₂O 

Relevant articles and documents

Development of multikilogram continuous flow cyclopropanation of N -benzylmaleimide through kinetic analysis

A convenient and high-yielding method for the synthesis of trans-(dioxo)-azabicyclo-[3.1.0]-hexane carboxylate, a key intermediate of complex molecules, is presented using a flow cyclopropanation process. From a detailed kinetic study, it is demonstrated that the reaction concentration, addition time of reagents, and initial mixing temperature are the critical parameters to minimize formation of byproducts and to get high reaction yield. Using a modular tubular flow reactor, the trans/cis-(dioxo)-azabicyclo-[3.1.0]-hexane carboxylate was obtained in 92% yield and isomerized under basic conditions to produce the trans-isomer in greater than 99% diastereomeric excess. Using this approach, the reaction yield was significantly increased compared to the batch process, and the robustness and reproducibility of this flow process was demonstrated for the synthesis of this key intermediate on a multikilogram scale.

3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: A novel series of mGluR2 positive allosteric modulators

The synthesis and structure-activity relationship (SAR) of a novel series of 3-(imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers, derived from a high throughput screening (HTS), are described. Subsequent optimization led to identification of potent, metabolically stable and orally available mGluR2 positive allosteric modulators (PAMs).

Synthesis of new fluoroquinolones and evaluation of their in vitro activity on Toxoplasma gondii and Plasmodium spp.

The synthesis of four new computer-designed fluoroquinolones which have been predicted by QSAR analysis to be active against the protozoa Toxoplasma gondii is described. These compounds are inhibitory in vitro for T. gondii. One of these compounds has a remarkably high activity comparable to that of trovafloxacin. It combines the basic cyclopropyl-quinoline structure of gatifloxacin or moxifloxacin with the C-7 6-amino-3-azabicyclo[3.1.0]hexyl side chain of trovafloxacin. The four compounds are also inhibitory for blood stages of Plasmodium falciparum though at high concentration. These results confirm the potential of quinolones as anti-T. gondii and antimalarial drugs but also show that the QSAR models for T. gondii cannot be reliably extended for screening antimalarial activity.