174469-41-1

Upstream product

• 102-96-5 (2-nitroethenyl)benzene 
• 39903-01-0 2-amino-3-hydroxy-5-bromopyridine 
• 21594-52-5 6-bromo-3H-oxazolo[4,5-b]pyridin-2-one 
• 65-85-0 benzoic acid 

Downstream Products

• 174469-34-2 6-benzyl-2-phenyloxazolo<4,5-b>pyridine 
• 174469-38-6 (2-phenyloxazolo<4,5-b>pyridin-6-yl)methanoic acid 
• 174469-39-7 (2-phenyloxazolo<4,5-b>pyridin-6-yl)methanoyl chloride 
• 174469-37-5 (2-phenyloxazolo<4,5-b>pyridin-6-yl)carboxaldehyde 
• 174469-35-3 (E)-3-(2-phenyloxazolo<4,5-b>pyridin-6-yl)acrylic acid methyl ester 

Relevant academic research and scientific papers

Ce(III)-catalyzed highly efficient synthesis of pyridyl benzamides from aminopyridines and nitroolefins without external oxidants

An efficient synthesis of a variety of pyridyl benzamides from 2-aminopyridines and nitroolefins is described. This rare-earth-metal-catalyzed reaction provides the corresponding products with broad substrate scope in moderate to excellent yields, in the absence of additives and external oxidants. Water is used as the source of the carbonyl oxygen atom in pyridyl benzamides. Furthermore, 2-substituted oxazolo[4,5-b]pyridines are formed in good yields under the standard conditions when 2-aminopyridin-3-ols are used as the substrates.

METHODS FOR TREATING SPINAL MUSCULAR ATROPHY

The present invention provides nucleic acid constructs, methods for identifying and validating compounds that increase the inclusion of exon 7 of SMN2 into mRNA transcribed from the SMN2 gene, compounds and pharmaceutical compositions that increase levels of SMN protein produced from the SMN2 gene, and methods for use thereof in treating of SMA.

HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE

Provided is a novel heterocyclic compound which is useful as a material for an organic electroluminescent device. The heterocyclic compound is represented by the general formula [I]: wherein X represents a nitrogen atom or a carbon atom; Y represents O or S; R1 and R2 each represent, independently of one another, a group selected from the group consisting of a substituted or unsubstituted alkyl group and the like; a represents 0 or more and 3 or less; b represents 0 or more and 3 or less; and Ar1 represents a substituted or unsubstituted heterocyclic ring or the like; and n represents an integer of 2 to 10.

SYNTHESIS OF 6-SUBSTITUTED 2-PHENYLOXAZOLOPYRIDINES

The synthesis of 2-phenyloxazolopyridines substituted in position 6 by alkyl, aryl, benzyl, formyl, acetyl, benzoyl and nitrile group is described.