176771-66-7Relevant academic research and scientific papers
Structure-based design of novel HIV protease inhibitors: Sulfonamide-containing 4-hydroxycoumarins and 4-hydroxy-2-pyrones as potent non-peptidic inhibitors
Thaisrivongs, Suvit,Janakiraman, Musiri N.,Chong, Kong-Teck,Tomich, Paul K.,Dolak, Lester A.,Turner, Steve R.,Strohbach, Joseph W.,Lynn, Janet C.,Horng, Miao-Miao,Hinshaw, Roger R.,Watenpaugh, Keith D.
, p. 2400 - 2410 (2007/10/03)
The low oral bioavailability and rapid biliary excretion of peptide-derived HIV protease inhibitors have limited their utility as potential therapeutic agents. Our broad screening program to discover non-peptidic HIV protease inhibitors previously identif
