174485-41-7

Usage

Uses

Used in Pharmaceutical Production:
1,5-BIS-(4-FLUORO-PHENYL)-PENTAN-3-ONE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of therapeutic agents with desired biological activities.
Used in Organic Synthesis:
1,5-BIS-(4-FLUORO-PHENYL)-PENTAN-3-ONE is used as a reagent in organic synthesis for its capacity to facilitate the creation of a wide range of organic compounds, enhancing the diversity and complexity of chemical libraries.
Used in Medicinal Chemistry and Drug Design:
1,5-BIS-(4-FLUORO-PHENYL)-PENTAN-3-ONE is used as a structural component in medicinal chemistry and drug design for its potential to influence the properties and efficacy of new therapeutic agents, contributing to advancements in the treatment of various diseases and conditions.

Upstream product

• 459-56-3 4-fluorobenzylic alcohol 
• 67-64-1 acetone 
• 405-99-2 para-fluorostyrene 
• 459-31-4 3-(4-fluorophenyl)propanoic acid 
• 147636-36-0 1-[(4-methylphenyl)sulfonyl]piperidine-4-carboxylic acid 
• 93-97-0 benzoic acid anhydride 
• 459-57-4 4-fluorobenzaldehyde 
• 53369-00-9 1,5-bis(4-fluorophenyl)penta-1,4-dien-3-one 
• 100-46-9 benzylamine 
• 33386-21-9 (1E,4E)-1,5-bis(4-fluorophenyl)penta-1,4-dien-3-one 

Downstream Products

• 946838-95-5 (4S,5S)-2,2-[bis-(2-(4-fluorophenyl)ethyl)]-N,N,N',N'-tetrakis[(4-methylphenyl)methyl]-1,3-dioxolane-4,5-dimethanamine 

Relevant academic research and scientific papers

Highly productive α-alkylation of ketones with alcohols mediated by an Ir-oxalamidato/solid base catalyst system

An Ir-oxalamidato complex in combination with a solid base (e.g., magnesium aluminometasilicate/Ca(OH)2) significantly improved the catalyst productivity in α-alkylation of methyl ketones with primary alcohols. Optimization through systematic variation of the oxalamidato ligand led to a practical turnover number (TON) of 10 000.40 000.

A Radical Approach to Anionic Chemistry: Synthesis of Ketones, Alcohols, and Amines

Historically accessed through two-electron, anionic chemistry, ketones, alcohols, and amines are of foundational importance to the practice of organic synthesis. After placing this work in proper historical context, this Article reports the development, f

Direct Use of Carboxylic Acids in the Photocatalytic Hydroacylation of Styrenes to Generate Dialkyl Ketones

A general protocol for the hydroacylation of styrenes from aliphatic carboxylic acids is reported. These reactions proceed via β-scission of a phosphoranyl radical that is accessed by photoredox catalysis, followed by addition of the resulting acyl radical to the styrenyl olefin. We show that phosphine tunability is critical for efficient intermolecular coupling due to competitive quenching of the photocatalyst by the olefin. Primary, secondary, and structurally rigid tertiary carboxylic acids all generate valuable unsymmetrical dialkyl ketones.

Tandem hydrogenation and condensation of fluorinated α,β-unsaturated ketones with primary amines, catalyzed by nickel

A simple homogeneous catalytic system based on nickel phosphine complexes has been developed for the transfer hydrogenation and condensation of α,β-unsaturated ketones to yield saturated ones and saturated imines using primary amines as hydrogen donors. Thus, a wide range of fluorinated 1,5-diaryl-1,4-pentadiene-3-ones were allowed to react with substituted benzylamines in the presence of [(dippe)Ni(μ-H)]2 (dippe = 1,2-bis-(diisopropylphosphino)-ethane) using ethanol as a solvent at 180 °C to give the corresponding saturated carbonyl compounds; here hydrogenation of the CC bond was preferred over the CO bond. Under the same reaction conditions but using an excess of benzylamine, a tandem process is then favoured, starting also with the reduction of the CC bond followed by a nucleophilic addition of the primary amine to yield valuable saturated imines with good to excellent yields (62%-91%).

Enantio- and diastereoselective catalytic mannich-type reaction of a glycine schiff base using a chiral two-center phase-transfer catalyst

(Chemical Equation Presented) Optically active α,β-diamino acids are prepared under asymmetric phase-transfer reaction conditions from a glycine Schiff base and N-protected imines with a tartrate-derived diammonium salt (TaDiAS) as the phase-transfer cata

PYRANONE COMPOUNDS USEFUL TO TREAT RETROVIRAL INFECTIONS

The present invention relates to compounds of formulae (I) and (II) which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl[b]pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus, wherein R 10 and R 20 taken together are formulae (III) and (IV). STR1