17449-76-2

Basic information

• Product Name: METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE
• Synonyms: HYDROXYCYCLOHEXANECARBOXYLIC ACID METHYL ESTER;METHYL 4-HYDROXYCYCLOHEXANE-1-CARBOXYLATE;METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE;4-Hydroxycyclohexanecarboxylic acid methyl ester;Cyclohexanecarboxylic acid, 4-hydroxy-, methyl ester;4-(Methoxycarbonyl)cyclohexan-1-ol, 1-Hydroxy-4-(methoxycarbonyl)cyclohexane
• CAS NO: 17449-76-2
• Molecular Formula: C₈H₁₄O₃
• Molecular Weight: 158.19
• EINECS: 241-464-6
• Product Categories: pharmacetical;Esters;Ring Systems
• Mol File: 17449-76-2.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 233℃
• Flash Point: 94℃
• Appearance: /
• Density: 1.121
• Vapor Pressure: 8.14E-06mmHg at 25°C
• Refractive Index: 1.681
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.96±0.40(Predicted)
• CAS DataBase Reference: METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE(17449-76-2)
• EPA Substance Registry System: METHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE(17449-76-2)

Safety Data

• Hazardous Substances Data: 17449-76-2(Hazardous Substances Data)

Usage

General Description

Methyl 4-hydroxycyclohexanecarboxylate is a chemical compound with the molecular formula C8H12O3. It is commonly used in the production of fragrances and flavoring agents due to its sweet, fruity odor and taste. It is also used as a building block in the synthesis of pharmaceuticals and fine chemicals. Methyl 4-hydroxycyclohexanecarboxylate is a colorless liquid with a high boiling point, making it suitable for a wide range of industrial applications. It is important to handle this compound with care as it may cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C7H4BrN3O2/c8-6-2-5(11(12)13)1-4(3-9)7(6)10/h1-2H,10H2

Upstream product

• 3685-26-5 trans-4-hydroxycyclohexanecarboxylic acid 
• 74-88-4 methyl iodide 
• 6297-22-9 4-carbomethoxycyclohexanone 
• 3685-22-1 4-hydroxycyclohexanecarboxylic acid 
• 99-96-7 4-hydroxy-benzoic acid 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 67-56-1 methanol 
• 186581-53-3 diazomethane 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 874-61-3 4-oxocyclohexanecarboxylic acid 

Downstream Products

• 1239311-08-0 methyl cis-4-[4-(5-cyclopentyloxymethyl[1.3.4]thiadiazol-2-ylcarbamoyl)phenoxy]cyclohexanecarboxylate 
• 1239311-06-8 cis-4-[4-(5-cyclopentyloxymethyl[1,3,4]thiadiazol-2-ylcarbamoyl)phenoxy]cyclohexanecarboxylic acid 
• 1239310-91-8 cis-4-(4-methoxycarbonylcyclohexyloxy)benzoic acid 
• 1239311-09-1 methyl cis-4-(4-chlorocarbonylphenoxy)cyclohexanecarboxylate 
• 1239311-10-4 methyl cis-4-(4-isothiocyanatocarbonylphenoxy)cyclohexane-carboxylate 
• 1239310-90-7 tert-butyl cis-4-(4-methoxycarbonylcyclohexyloxy)benzoate 

Relevant articles and documents

Trans-Selective and Switchable Arene Hydrogenation of Phenol Derivatives

A trans-selective arene hydrogenation of abundant phenol derivatives catalyzed by a commercially available heterogeneous palladium catalyst is reported. The described method tolerates a variety of functional groups and provides access to a broad scope of trans-configurated cyclohexanols as potential building blocks for life sciences and beyond in a one-step procedure. The transformation is strategically important because arene hydrogenation preferentially delivers the opposite cis-isomers. The diastereoselectivity of the phenol hydrogenation can be switched to the cis-isomers by employing rhodium-based catalysts. Moreover, a protocol for the chemoselective hydrogenation of phenols to cyclohexanones was developed.

FACTOR XIA-INHIBITING PYRIDOBENZAZEPINE AND PYRIDOBENZAZOCINE DERIVATIVES

The invention relates to substituted pyridobenzazepine and pyridobenzazocine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

NOVEL CARBOXYLIC ACID COMPOUNDS USEFUL FOR INHIBITING MICROSOMAL PROSTAGLANDIN E2 SYNTHASE-1

The present invention provides compounds of Formula 1, or a pharmaceutically acceptable salts, thereof, where R, X, A, E, and G are as described herein, methods of preparing the compounds, and use of the compounds to treat pain and/or inflammation.