174498-03-4Relevant articles and documents
Methanocarba modification of uracil and adenine nucleotides: High potency of northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors
Hak Sung Kim,Ravi,Marquez,Maddileti,Wihlborg,Erlinge,Malmsj?,Boyer,Harden,Jacobson
, p. 208 - 218 (2002)
The potency of nucleotide antagonists at P2Y1 receptors was enhanced by replacing the ribose moiety with a constrained carbocyclic ring (Nandanan, et al. J. Med. Chem. 2000, 43, 829-842). We have now synthesized ring-constrained methanocarba an
Adenine nucleotide analogues locked in a Northern methanocarba conformation: Enhanced stability and potency as P2Y1 receptor agonists
Ravi, R. Gnana,Kim, Hak Sung,Servos, J?rg,Zimmermann, Herbert,Lee, Kyeong,Maddileti, Savitri,Boyer, José L.,Harden, T. Kendall,Jacobson, Kenneth A.
, p. 2090 - 2100 (2007/10/03)
Preference for the Northern (N) ring conformation of the ribose moiety of nucleotide 5′-triphosphate agonists at P2Y1, P2Y2, P2Y4, and P2Y11 receptors, but not P2Y6 receptors, was established using a
4',1'a-METHANOCARBOCYCLIC ADENOSINE ANALOGUES AS POTENTIAL INHIBITORS OF S-ADENOSYLHOMOCYSTEINE HYDROLASE
Jeong, Lak S.,Marquez, Victor E.,Yuan, Chong-Shen,Borchardt, Ronald T.
, p. 2651 - 2656 (2007/10/03)
Cyclopropane-fused carbocyclic adenosine (4) and its 5'-carboxaldehyde analogue (5) were synthesized as potential inhibitors of S-adenosylhomocysteine hydrolase.The key bicyclohexane alcohol (8) was obtained from the optically pure cyclopentenone s
