174522-72-6

Upstream product

• 29984-62-1 4-amino-2-phenyl-pteridine-7-one 
• 75-09-2 dichloromethane 
• 21740-23-8 3,5-O-bis(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride 
• 29984-62-1 4-amino-2-phenyl-7(8H)-pteridinone 

Downstream Products

• 174522-73-7 4-Amino-2-phenyl-8-(2-deoxy-β-D-ribofuranosyl)pteridine-7-one 
• 195442-58-1 4-Amino-8-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-phenyl-8H-pteridin-7-one 

Relevant academic research and scientific papers

Pteridine nucleotide analogs as fluorescent DNA probes

The invention provides novel pteridine nucleotides which are highly fluorescent under physiological conditions and which may be used in the chemical synthesis of fluorescent oligonucleotidcs. The invention further provides for fluorescent oligonucleotides comprising one or more pteridine nucleotides. In addition the invention provides for pteridine nucleotide triphosphates which may be used as the constituent monomers in DNA amplification procedures.

A new efficient method in nucleoside synthesis

A new stereo- and regioselective synthesis for adenosine analogous nucleosides is described. Starting from 2- and 6-substituted 4-amino-7(8H)-pteridinones, DBU deprotonation and the ribosylation with an α-haloribofuranose derivative leads to the corresponding pteridine-N-8-β-D-nucleosides in reasonably good yields.