174534-47-5

Upstream product

• 110-89-4 piperidine 
• 139210-05-2 (E)-3-(2-Phenyliminomethyleneamino-phenyl)-acrylic acid methyl ester 
• 138386-58-0 (2E)-3-{2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester 
• 103-71-9 phenyl isocyanate 
• 612-41-9 2-nitrocinnamic acid 
• 659748-14-8 methyl 3-[2-(3-phenylureido)phenyl]acrylate 
• 88939-75-7 methyl (2E)-3-(2-aminophenyl)propenoate 
• 39228-29-0 (E)-methyl 2-nitrocinnamate 
• 139210-05-2 methyl 3-[2-(phenyliminomethyleneamino)phenyl]acrylate 

Downstream Products

• 200571-81-9 (3-Phenyl-2-piperidin-1-yl-3,4-dihydro-quinazolin-4-yl)-acetic acid 
• 742104-68-3 KYS₀₅₀₄₀ 
• 742104-57-0 KYS₀₅₀₃₄ 

Relevant academic research and scientific papers

T-type Ca2+ channel blockers suppress the growth of human cancer cells

In order to further clarify the role of T-type Ca2+ channels in cell proliferation, we have measured the growth inhibition of human cancer cells by using our potent T-type Ca2+ channel blockers. As a result, KYS05090, a most potent T-type Ca2+ channel blocker, was found to be as potent as doxorubicin against some human cancer cells without acute toxicity. Therefore, this letter provides the biological results that T-type calcium channel is important in regulating the important cellular phenotype transition leading to cell proliferation, and thus novel T-type Ca2+ channel blocker presents new prospects for cancer treatment.

Synthesis and SAR studies of a novel series of T-type calcium channel blockers

For the novel, potent, and selective T-type Ca2+ channel blockers, a series of sulfonamido-containing 3,4-dihydroquinazoline derivatives were prepared and evaluated for their blocking actions on T- and N-type Ca2+ channels. Among the

3,4-Dihydroquinazoline derivatives as T-type calcium channel blockers and method of preparing the same

The present invention relates to 3,4-dihydroquinazoline derivatives as T-type calcium channel blockers and a method of preparing the same. The present invention further relates to a composition comprising the same. The composition comprising the 3,4-dihyd

3,4-Dihydroquinazoline derivatives as T-type calcium channel blockers and method of preparing the same

The present invention relates to 3,4-dihydroquinazoline derivatives as T-type calcium channel blockers and a method of preparing the same. The present invention further relates to a composition comprising the same. The composition comprising the 3,4-dihyd

A facile and efficient carbodiimide-mediated synthesis of dihydroquinazolines via a tandem nucleophilic addition-intramolecular hetero conjugate addition annulation strategy

A novel and efficient method is described for the synthesis of dihydroquinazoline derivatives which involves initial addition of a nucleophile (alcohol, amine and thiol) to the carbodiimide cumulenic system followed by intramolecular hetero conjugate addition annulation.