200571-81-9Relevant academic research and scientific papers
Solid-phase synthesis of 3,4-dihydroquinazoline
Wang, Fengjiang,Hauske, James R.
, p. 8651 - 8654 (1997)
A novel, facile and efficient method for the synthesis of aryl iminophosphorane has been developed by treating a series of Ar-NH2 (1) attached to a solid support with Ph3P and diethyl azodicarboxylate at room temperature. The resulting solid-supported cinnamyl iminophosphorane (4) was treated with an aryl isocyanate to generate the corresponding solid-supported carbodiimide (5), which upon exposure to a secondary amine underwent 1,2-addition followed by an intramolecular Michael addition to afford the desired 3,4-dihydroquinazoline (7).
T-type Ca2+ channel blockers suppress the growth of human cancer cells
Heo, Jae Ho,Seo, Han Na,Choe, Yun Jeong,Kim, Sujin,Oh, Chun Rim,Kim, Young Deuk,Rhim, Hyewhon,Choo, Dong Joon,Kim, Jungahn,Lee, Jae Yeol
scheme or table, p. 3899 - 3901 (2009/04/10)
In order to further clarify the role of T-type Ca2+ channels in cell proliferation, we have measured the growth inhibition of human cancer cells by using our potent T-type Ca2+ channel blockers. As a result, KYS05090, a most potent T-type Ca2+ channel blocker, was found to be as potent as doxorubicin against some human cancer cells without acute toxicity. Therefore, this letter provides the biological results that T-type calcium channel is important in regulating the important cellular phenotype transition leading to cell proliferation, and thus novel T-type Ca2+ channel blocker presents new prospects for cancer treatment.
Synthesis and SAR studies of a novel series of T-type calcium channel blockers
Park, Seong Jun,Park, Sung Jun,Lee, Min Joo,Rhim, Hyewhon,Kim, Yoonjee,Lee, Jung-Ha,Chung, Bong Young,Lee, Jae Yeol
, p. 3502 - 3511 (2007/10/03)
For the novel, potent, and selective T-type Ca2+ channel blockers, a series of sulfonamido-containing 3,4-dihydroquinazoline derivatives were prepared and evaluated for their blocking actions on T- and N-type Ca2+ channels. Among the
3,4-Dihydroquinazoline derivatives as novel selective T-type Ca 2+ channel blockers
Lee, Yong Sup,Lee, Bum Hoon,Park, Seong Jun,Kang, Soon Bang,Rhim, Hyewhon,Park, Jin-Yong,Lee, Jung-Ha,Jeong, Seong-Woo,Lee, Jae Yeol
, p. 3379 - 3384 (2007/10/03)
For LVA T-type Ca2+ channel blockers, 3,4-dihydroquinazoline derivatives as new scaffolds were prepared and evaluated for the inhibitory activity against two members of the recombinant T-type Ca2+ channel family. Among them, 8a (KYS0
