17462-08-7Relevant academic research and scientific papers
N-Acylation of 3-Amino-1,2-propanediol with Amino Acids
Angrick, Michael,Rewicki, Dieter
, p. 1394 - 1397 (2007/10/02)
Racemic 3-amino-1,2-propanediol was selectively N-acylated by several Z (S)-amino acids using 1,1'-carbonyldiimidazole as coupling reagent and tetrahydrofuran as solvent.In some cases (alanine, valine, phenylalanine) one of the two diastereomeric amides formed precipitates spontaneously and can be easily separated.In the case of alanine, the S,S-configuration of the isolated amide was proved.The protective Z groups were removed by catalytic hydrogenation to yield the hydrophilic oily amides.
