174623-83-7

Upstream product

• 2304-96-3 N-benzyloxycarbonyl-L-asparagine 
• 3256-57-3 N-benzyloxycarbonyl-L-asparagine p-nitrophenyl ester 
• 51644-96-3 5-tert-butoxycarbonylamino-1-aminopentane 
• 462-94-2 1,5-diaminopentane 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 125718-81-2 (5-{(S)-2-[2-(2,4-Bis-benzyloxy-phenyl)-acetylamino]-3-carbamoyl-propionylamino}-pentyl)-carbamic acid tert-butyl ester 
• 113954-15-7 (S)-N¹-(5-Amino-pentyl)-2-[2-(2,4-bis-benzyloxy-phenyl)-acetylamino]-succinamide 
• 125718-78-7 (S)-N¹-(5-Amino-pentyl)-2-[2-(2,4-bis-benzyloxy-phenyl)-acetylamino]-succinamide; hydrochloride 
• 125739-24-4 (S)-N¹-(5-{3-[4-((S)-2-Amino-5-guanidino-pentanoylamino)-butylamino]-propionylamino}-pentyl)-2-[2-(2,4-dihydroxy-phenyl)-acetylamino]-succinamide; hydrochloride 

Relevant academic research and scientific papers

Practical, convergent total synthesis of polyamine amide spider toxin NSTX-3

A practical, total synthesis of polyamine amide spider toxin NSTX-3, a potent glutamate receptor antagonist with potential as a neuroprotective agent, is reported. The unsymmetrical polyamine moiety was built by a conjugate addition to afford putreanine and regioselective acylation of L-asparaginyl-cadaverine.

Synthesis of Neurotoxic Nephila Spider Venoms: NSTX-3 and JSTX-3

Efficient and practical synthetic routes to the polyamine spider venom principles, NSTX-3 and JSTX-3 are described.