Practical, convergent total synthesis of polyamine amide spider toxin NSTX-3

DOI: 10.1016/0040-4039(95)02238-4

Source and publish data:

Tetrahedron Letters p. 551 - 554 (1996)

Update date:2022-07-29

Topics:

Authors:

Blagbrough, Ian S.

Moya, Eduardo

Walford, Steven P.

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Article abstract of DOI:10.1016/0040-4039(95)02238-4

A practical, total synthesis of polyamine amide spider toxin NSTX-3, a potent glutamate receptor antagonist with potential as a neuroprotective agent, is reported. The unsymmetrical polyamine moiety was built by a conjugate addition to afford putreanine and regioselective acylation of L-asparaginyl-cadaverine.

Full text of DOI:10.1016/0040-4039(95)02238-4

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