Tetrahedron Letters p. 551 - 554 (1996)
Update date:2022-07-29
Topics:
Blagbrough, Ian S.
Moya, Eduardo
Walford, Steven P.
A practical, total synthesis of polyamine amide spider toxin NSTX-3, a potent glutamate receptor antagonist with potential as a neuroprotective agent, is reported. The unsymmetrical polyamine moiety was built by a conjugate addition to afford putreanine and regioselective acylation of L-asparaginyl-cadaverine.
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(1996)
