17464-22-1Relevant academic research and scientific papers
One-pot synthesis of 1,3,4-thiadiazoles using Vilsmeier reagent as a versatile cyclodehydration agent
Zarei, Maaroof
, p. 1867 - 1872 (2017/03/11)
A simple and efficient synthetic method for the one-pot synthesis of 1,3,4-thiadiazoles utilizing Vilsmeier reagent was developed. In this method carboxylic acids and hydrazine were converted to 1,3,4-thiadiazoles in the presence of Vilsmeier reagent and Lawesson's reagent. The influence of the thionation reagent, solvent, temperature and time, in this reaction was discussed. The developed methodology for 1,3,4-thiadiazole synthesis has the advantage of simplicity, ambient reaction conditions, easy purification and good to excellent yield of products.
Liquid Crystalline 1,3,4-Thiadiazoles. 1. Biphenyl- and Terphenyl Analogous 1,3,4-Thiadiazoles
Dimitrowa, K.,Hauschild, J.,Zaschke, H.,Schubert, H.
, p. 933 - 944 (2007/10/02)
The synthesis of disubstituted 1,3,4- and 1,2,4-thiadiazoles and 1,3,4-oxadiazoles is described and their melting and clearing points are investigated.The influence of the heterocyclic ring system on the formation of crystalline liquid phases is discussed
