17467-33-3Relevant academic research and scientific papers
Copper-Catalyzed Aerobic Oxidative [3+2] Annulation for the Synthesis of 5-Amino/Imino-Substituted 1,2,4-Thiadiazoles through C-N/N-S Bond Formation
Yu, Wentao,Huang, Yubing,Li, Jianxiao,Tang, Xiaodong,Wu, Wanqing,Jiang, Huanfeng
, p. 9334 - 9343 (2018/07/30)
A copper-catalyzed aerobic oxidative annulation reaction of 2-aminopyridine/amidine with isothiocyanate has been reported. This strategy involving C-N/N-S bond formations provides various 5-amino/imino-substituted 1,2,4-thiadiazole derivatives under a Cu/O2 catalytic system. This method has demonstrated high reactivity, mild reaction conditions, and a broad substrate scope. Furthermore, the synthetic utilities of the approach are demonstrated by further modifications.
Substituted 5-amino-1,2,4-thiadiazoles with pharmaceutical activity
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, (2008/06/13)
Pharmaceutical compounds of the following formula are described: in which R1 is hydrogen, C1 4 alkyl, C1 4 alkoxy-C1 4 alkyl, hydroxy-C1 4 alkyl, optionally substituted phenyl, optionally substituted phenyl-C1 4 alkyl or a heterocycle selected from: where R3 is hydrogen, C1 4 alkyl, C1 4 alkoxy, nitro, halo, cyano, trifluoromethyl, carboxyl or -CONH2, and R4 is C1 4 alkyl; and R2 is hydrogen, C1 4 alkyl, phenyl or thienyl substituted with a carboxyl or C1 4 alkoxy-carbonyl group, an acyl group of the formula R5CO- where R5 is hydrogen, C1 4 alkyl, C1 4 alkoxy-C1 4 alkyl, halo C1 4 alkyl, C1 4 alkoxy, halo-C1 4 alkoxy, phenyl, phenyl-C1 4 alkyl, -NHC1 4 alkyl, -NH phenyl or where R6 is C1 4 alkyl, or a group of the formula -CH=C(COC1 4 alkoxy)2; or a salt thereof.
Amidrazones. 6(1). Synthesis of 1,2,4-Thiadiazoles by Thermolysis of N3-Thiocarbamoylamidrazone Ylides
Smith, Richard F.,Feltz, Timothy P.
, p. 201 - 203 (2007/10/02)
Reaction of N3-unsubstituted amidrazone ylides (1a and 1b) with alkyl or aryl isothiocyanates gives N3-thiocarbamoylamidrazone ylides (2).Thermolysis of 2 gives 3-alkyl(or aryl)-5-alkyl(or aryl)amino-1,2,4-thiadiazoles (a-i).
