174672-06-1

Usage

Uses

Used in Pharmaceutical Industry:
5-Chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole is used as a pharmaceutical agent for its potential activity against various pathogens, such as bacteria and fungi. Its unique structure and reactivity contribute to its potential as a valuable target for medicinal chemistry research, aiding in the development of new drugs for the treatment of infectious diseases.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 5-Chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole serves as a valuable target for research, due to its unique structure and reactivity. 5-Chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole's potential as a pharmaceutical agent makes it instrumental in the discovery and development of new drugs for the treatment of infectious diseases, offering a promising avenue for combating bacterial and fungal infections.

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Relevant academic research and scientific papers

FLOW REACTION PROCESS FOR MANUFACTURE OF BORON-CONTAINING AGROCHEMICALS

The present invention relates to methods of preparing benzoxaboroles. Benzoxaborole compounds have shown promise as antimicrobial agents, especially against fungal pathogens. The invention also relates to compositions of acyclic alkoxy boronic acid esters as intermediates, and continuous flow processes of mixing the intermediates with organomagnesium, magnesium, or organolithium reagents to form the desired benzoxaboroles.

Benzoxaborole-1-alcohol compound and preparation method and application thereof

The invention belongs to the field of bactericides, and particularly relates to a benzoxaborole-1-alcohol compound and a preparation method and application thereof. The benzoxaborole-1-alcohol compound has good bactericidal activity, can effectively control tomato early blight, wheat scab, rice sheath blight disease, strawberry gray mold, apple blotch, cucumber anthracnose and other crop diseases,can produce excellent antibacterial effects at low concentration, and shows good selectivity. The compound is used as a leucyl-tRNA synthetase inhibitor, the evolution difference of aminoacyl-tRNA synthetase of germs and eukaryotes is utilized, and the compound has very high safety to non-target organisms while killing the germs and can be used as a bactericide in agriculture.

Compounds for the Treatment of Periodontal Disease

Compounds, compositions and methods are provided which are useful in the treatment of periodontal disease.

Hydrolytically-Resistant Boron-Containing Therapeutics And Methods Of Use

Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.

BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS

Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.

Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro- 1-hydroxy-2,1-benzoxaborole (AN2690), for the potential treatment of onychomycosis

A structure-activity relationship investigation for a more efficacious therapy to treat onychomycosis, a fungal infection of the toe and fingernails, led to the discovery of a boron-containing small molecule, 5-fluoro-1,3-dihydro- 1-hydroxy-2,1-benzoxaborole (AN2690), which is currently in clinical trials for onychomycosis topical treatment.

Boron-containing small molecules

This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.

Oxaboroles and salts thereof, and their use as biocides

A method for the protection of a medium by susceptible to microbial attack by the treatment of the medium with an oxaborale or a salt of an oxaborale.