174699-77-5

Basic information

• Product Name: (R)-(-)-2-broMo-1-(3'-chlorophenyl) ethanol
• Synonyms: (R)-(-)-2-broMo-1-(3'-chlorophenyl) ethanol
• CAS NO: 174699-77-5
• Molecular Formula: C₈H₈BrClO
• Molecular Weight: 235.50552
• Mol File: 174699-77-5.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-(-)-2-broMo-1-(3'-chlorophenyl) ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(-)-2-broMo-1-(3'-chlorophenyl) ethanol(174699-77-5)
• EPA Substance Registry System: (R)-(-)-2-broMo-1-(3'-chlorophenyl) ethanol(174699-77-5)

Safety Data

• Hazardous Substances Data: 174699-77-5(Hazardous Substances Data)

Upstream product

• 41011-01-2 2-bromo-1-(3-chloro-phenyl)-ethanone 
• 37577-28-9 (1S,2R)-(+)-norphedrine 
• 77-78-1 dimethyl sulfate 
• 4276-09-9 (R)-2-amino-3-methylbutanol 
• 22651-87-2 cyclohexanecarboxylic acid anhydride 
• 117538-45-1 2-bromo-1-(3-chlorophenyl)ethanol 
• 934001-82-8 1-(bromoethynyl)-3-chlorobenzene 
• 187409-10-5 3-chloro-α,β-dibromoethylbenzene 
• 99-02-5 3'-Chloroacetophenone 

Downstream Products

• 20697-04-5 (R)-meta-chlorostyrene oxide 

Relevant articles and documents

Chiral guanidine catalyzed acylative kinetic resolution of racemic 2-bromo-1-arylethanols

In this study, chiral guanidine catalyzed acylative kinetic resolution of racemic 2-bromo-1-arylethanols was achieved with high selectivity. Irrespective of the electronic nature and the substitution patterns on the aromatic rings, a variety of substrates were suitable for this reaction. The branched acyl component was considered to be optimal for obtaining high s-values. The transition state of the reaction was proposed based on the absolute configuration of the obtained product.

Integration of multiple active sites on large-pore mesoporous silica for enantioselective tandem reactions

Facile construction of a multifunctional heterogeneous catalyst through the assembly of Au/carbene and chiral ruthenium/diamine dual complexes in large-pore mesoporous silica was developed. This enables an efficient one-pot hydration-asymmetric transfer hydrogenation enantioselective tandem reaction of haloalkynes, affording chiral halohydrins with up to 99% enantioselectivity. Combined multifunctionalities, such as substrate-promoted silanol-functionality, BF4? anion-bonding gold/carbene and covalent-bonding chiral ruthenium/diamine active centers, contributed cooperatively to the catalytic performance.

The Ru-catalyzed enantioselective preparation of chiral halohydrins and their application in the synthesis of (R)-clorprenaline and (S)-sotalol

The asymmetric transfer hydrogenation of a series of halo-substituted aryl methyl ketones, including those substituted in both α-methyl and aryl rings, was studied for the preparation of chiral halohydrins. Up to 99.7% ee was obtained with 2-chloro-1-(2-chlorophenyl)ethanone as the substrate and Ru-CsDPEN as the catalyst in an HCOONa/H2O system. (R)-Clorprenaline, a drug used in the treatment of respiratory disorders, such as bronchitis and asthma, and (S)-sotalol, a class-III antiarrhythmic compound, were prepared with these chiral halohydrins.