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(R)-1-(benzyloxycarbonyl)-3-((2-azetidynylmethyl)oxy)pyridine is a chemical compound characterized by a pyridine ring with a benzyloxycarbonyl group at the 1 position and an azetidynylmethyloxy group at the 3 position. (R)-1-(benzyloxycarbonyl)-3-((2-azetidynylmethyl)oxy)pyridine is utilized as a fundamental building block in the realms of organic synthesis and pharmaceutical research, where the benzyloxycarbonyl group serves as a protective agent for amines, and the azetidynylmethyloxy group is strategically employed to alter the molecular properties for medicinal chemistry purposes. Its potential applications extend to the development of novel drug molecules and it may also be utilized as a key intermediate in the synthesis of other bioactive compounds.

174740-83-1

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174740-83-1 Usage

Uses

Used in Pharmaceutical Research:
(R)-1-(benzyloxycarbonyl)-3-((2-azetidynylmethyl)oxy)pyridine is used as a building block for the development of new drug molecules, due to its unique structural features that allow for the creation of a diverse range of bioactive compounds.
Used in Organic Synthesis:
In the field of organic synthesis, (R)-1-(benzyloxycarbonyl)-3-((2-azetidynylmethyl)oxy)pyridine is used as a key intermediate, enabling the synthesis of a variety of complex organic molecules with potential applications in various industries.
Used in Medicinal Chemistry:
(R)-1-(benzyloxycarbonyl)-3-((2-azetidynylmethyl)oxy)pyridine is used as a modifying agent to alter the properties of molecules, potentially enhancing their efficacy, stability, or bioavailability in the context of drug design and development.
Used in the Synthesis of Bioactive Compounds:
(R)-1-(benzyloxycarbonyl)-3-((2-azetidynylmethyl)oxy)pyridine is also utilized as a key intermediate in the synthesis of other bioactive compounds, which may have applications in various therapeutic areas, including but not limited to, oncology, neurology, and cardiovascular medicine.

Check Digit Verification of cas no

The CAS Registry Mumber 174740-83-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,4,7,4 and 0 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 174740-83:
(8*1)+(7*7)+(6*4)+(5*7)+(4*4)+(3*0)+(2*8)+(1*3)=151
151 % 10 = 1
So 174740-83-1 is a valid CAS Registry Number.

174740-83-1Downstream Products

174740-83-1Relevant academic research and scientific papers

Novel 3-pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors

Abreo, Melwyn A.,Lin, Nan-Horng,Garvey, David S.,Gunn, David E.,Hettinger, Ann-Marie,Wasicak, James T.,Pavlik, Patricia A.,Martin, Yvonne C.,Donnelly-Roberts, Diana L.,Anderson, David J.,Sullivan, James P.,Williams, Michael,Arneric, Stephen P.,Holladay, Mark W.

, p. 817 - 825 (1996)

Recent evidence indicating the therapeutic potential of cholinergic channel modulators for the treatment of central nervous system (CNS) disorders as well as the diversity of brain neuronal nicotinic acetylcholine receptors (nAChRs) have suggested an opportunity to develop subtype-selective nAChR ligands for the treatment of specific CNS disorders with reduced side effect liabilities. We report a novel series of 3-pyridyl ether compounds which possess subnanomolar affinity for brain nAChRs and differentially activate subtypes of neuronal nAChRs. The synthesis and structure-activity relationships for the leading members of the series are described, including A-85380 (4a), which possesses ca. 50 pM affinity for rat brain [3H]-(- )cytisine binding sites and 163% efficacy compared to nicotine to stimulate ion flux at human α4β2 nAChR subtype, and A-84543 (2a), which exhibits 84- fold selectivity to stimulate ion flux at human α4β2 nAChR subtype compared to human ganglionic type nAChRs. Computational studies indicate that a reasonable superposition of a low energy conformer of 4a with (S)-nicotine and (-)-epibatidine can be achieved.

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