174748-61-9Relevant academic research and scientific papers
Generation and trapping of 5,6-dimethylenepyrimidin-4-ones in Diels-Alder and Michael additions
Tome, Augusto C.,Cavaleiro, Jose A. S.,Storr, Richard C.
, p. 1723 - 1734 (1996)
Pyrimidone fused sulfones 5-7 were obtained from the reaction of amidines with 3-methoxycarbonyl-4-oxotetrahydrothiophene followed by N-methylation and oxidation with mCPBA. On heating in solution at 150°C, extrusion of SO2 occurred to give the highly reactive 5,6-dimethylenepyrimidin-4-ones which were intercepted in situ in Diels-Alder reactions to give the adducts 24-28 and in conjugate addition reactions with thiol nucleophiles to give the thioethers 29 and 30.
