174754-65-5Relevant academic research and scientific papers
Prediction of the solvent dependence of enzymatic prochiral selectivity by means of structure-based thermodynamic calculations
Ke,Wescott,Klibanov
, p. 3366 - 3374 (1996)
A new, quantitative model is elaborated to rationalize the solvent dependence of enzymatic selectivity solely on the basis of the thermodynamics of substrate solvation. The model predicts that any type of the selectivity (defined as the ratio of k(cat)/K(
Palladium catalyzed direct benzylation/allylation of malonates with alcohols-: In situ C-O bond activation
Cao, Xueqin,Zhang, Yugen
supporting information, p. 2638 - 2641 (2016/05/24)
High step- and atom-economy are the endlessly pursued in organic and pharmaceutical syntheses. Herein, a new method for directly coupling benzyl/allyl alcohols with malonates via a palladium catalyzed Tsuji-Trost type reaction was developed. The reaction was carried out in an organic carbonate solvent which would activate alcohols in situ, replacing the traditional pre-synthesized carbonates. The new process demonstrated high efficiency, high selectivity and high generality. A wide variety of mono-substituted and bis-substituted malonates were selectively produced under different conditions, and this method represents a more step- and atom-economical and environmentally benign synthetic protocol.
