174758-16-8Relevant academic research and scientific papers
Novel vitronectin receptor antagonist derivatives, method for preparing same, use thereof as medicines and pharmaceutical compositions containing same
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Page/Page column 21-22, (2008/06/13)
A subject of the invention is the compounds of formula (I): in which R1, R2, R3, R4 and G have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
(1-Benzimidazolonyl)alanine (Bia): Preliminary investigations into a potential tryptophan mimetic
Huber, Vincent J,Arroll, Thomas W,Lum, Christopher,Goodman, Burton A,Nakanishi, Hiroshi
, p. 6729 - 6733 (2007/10/03)
The new amino acid (1-benzimidazolonyl)alanine (Bia) was synthesized as a potential biomimetic replacement of tryptophan. The replacement of tryptophan with this amino acid in a truncated analog of p53 showed nearly identical binding to HDM2 as the same l
Non-peptide fibrinogen receptor antagonists. 4. The synthesis of [3H]L-756,568
Hamill, Terence G.,Hutchinson, John H.,Brashear, Karen M.,Hartman, George D.
, p. 605 - 609 (2007/10/03)
The synthesis of [3H]L-756,568, an orally active fibrinogen receptor antagonist, is described. Two synthetic pathways were developed using either bromoindoles 2a/2b or bromoaryl sulfonamide 11 as the precursor. Use of the bromoaryl sulfonamide
