174813-24-2Relevant articles and documents
Supramolecular structures of four (Z)-5-arylmethylene-2-thioxothia-zolidin- 4-ones: Hydrogen-bonded dimers, chains of rings and sheets
Delgado, Paula,Quiroga, Jairo,Cobo, Justo,Low, John N.,Glidewell, Christopher
, p. o477-o482 (2005)
In each of the four title compounds, namely (Z)-S-benzyl-idene-2- thioxothiazolidin-4-one, C10H7NOS2, (I), which crystallizes with Z′ = 2 in space group P21/n, (Z)-5-(4-methylbenzylidene)-2-thioxothiazolidin-4-o
Synthesis, molecular modeling, selective aldose reductase inhibition and hypoglycemic activity of novel meglitinides
Salem, Manar G.,Abdel Aziz, Yasmine M.,Elewa, Marwa,Nafie, Mohamed S.,Elshihawy, Hosam A.,Said, Mohamed M.
, (2021)
In the present study, a novel generation of selective aldose reductase ALR2 inhibitors with significant hypoglycemic activities was designed and modulated based on rhodanine scaffold joined to an acetamide linker in between two lipophilic moieties. The synthesis of the novel compounds was accomplished throughout simple chemical pathways. Molecular docking was performed on B-cell membrane protein SUR1, aldehyde reductase ALR1 and aldose reductase ALR2 active sites. Compounds 10B, 11B, 12B, 15C, 16C, 26F and 27F displayed the highest hypoglycemic activities with 80.7, 85.2, 87, 82.3, 83.5, 81.4 and 85.3% reduction in blood glucose levels, respectively. They were more potent than the standard hypoglycemic agent repaglinide with 65.4% reduction in blood glucose level. Compounds 12B and 15C with IC50 0.29 and 0.35 μM were more potent than the standard ALR2 inhibitor epalrestat with IC50 0.40 μM. They were selective towards ALR2 over ALR1 134 and 116 folds, respectively. Molecular docking studies matched with the in-vitro and in-vivo results to elucidate the dual activities of both compounds 12B and 15C as potent antagonists for ALR2 over ALR1 and good agonists for the SUR1 protein.
Facile and convenient synthesis of 5-arylalkylidenerhodanines by electrocatalytic crossed aldol condensation
Veisi, Hojat,Vafajoo, Zahra,Maleki, Behrooz,Maghsoodlou, Malek Taher
, p. 672 - 677 (2013)
An electrochemically induced catalytic crossed Aldol condensation of one equivalent of rhodanine with various aromatic aldehydes and ketones in ethanol in an undivided cell in the presence of sodium bromide as an electrolyte results in the formation of th
Synthesis, molecular structure investigations and antimicrobial activity of 2-thioxothiazolidin-4-one derivatives
Barakat, Assem,Al-Najjar, Hany J.,Al-Majid, Abdullah Mohammed,Soliman, Saied M.,Mabkhot, Yahia Nasser,Al-Agamy, Mohamed H.M.,Ghabbour, Hazem A.,Fun, Hoong-Kun
, p. 519 - 529 (2015)
A variety of 2-thioxothiazolidin-4-one derivatives were prepared and their in vitro antimicrobial activities were studied. Most of these compounds showed significant antibacterial activity specifically against Gram-positive bacteria, among which compounds
The synthesis and SAR of rhodanines as novel class C β-lactamase inhibitors
Grant, Eugene B.,Guiadeen, Deodialsingh,Baum, Ellen Z.,Foleno, Barbara D.,Jin, Haiyong,Montenegro, Deborah A.,Nelson, Erin A.,Bush, Karen,Hlasta, Dennis J.
, p. 2179 - 2182 (2000)
β-Lactam antibiotics such as the cephalosporins and penicillins have diminished clinical effectiveness due to the hydrolytic activity of diverse β-lactamases, especially those in molecular classes A and C. A structure-activity relationship (SAR) study of
(Z)-5-[(5-Methyl-1H-imidazol-4-yl)methyl-idene]-2-sulfanyl-idene-1, 3-thia-zolidin-4-one monohydrate: A three-dimensional hydrogen-bonded framework structure
Insuasty, Alberto,Insuasty, Braulio,Cobo, Justo,Glidewell, Christopher
, p. o468-o471 (2012)
The non-H atoms in the organic component of the title compound, C8H7N3OS2·H2O, are almost coplanar, as the dihedral angle between the two ring planes is only 1.8 (2)°; there is a wide C - C - C angle of 127.8 (3)° at the methine C atom linking the two rin
Synthesis and spectroscopical study of rhodanine derivative using DFT approaches
Anbarasan,Dhandapani,Manivarman,Subashchandrabose,Saleem
, p. 261 - 272 (2015)
Abstract The optimized molecular structure, vibrational frequencies, corresponding vibrational assignments of (E)-5-benzylidene-2-thioxothiazolidine-4-one (E5BTTO) have been investigated experimentally and theoretically based on Density Functional Theory
New N-ribosides and N-mannosides of rhodanine derivatives with anticancer activity on leukemia cell line: Design, synthesis, DFT and molecular modelling studies
Awad, Mohamed K.,Elshaier, Yaseen A. M. M.,Gesson, Jean-Pierre,Khodair, Ahmed I.
, (2019/12/26)
N-ribosylation and N-mannosylation compounds have a great role in compounds activity as anticancer. The reaction of 2-thioxo-4-thiazolidinone (rhodanine) derivatives, as aglycon part, was done with ribofuranose and mannopyranose sugars (glycone part) foll
