174840-07-4

Upstream product

• 67-63-0 isopropyl alcohol 
• 164263-08-5 (R)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-pivaloyloxymethoxycarbonyl-3-pyridinecarboxylic acid 

Downstream Products

• 174840-08-5 (S)-isopropyl pivaloyloxymethyl 2-bromomethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate 
• 174840-10-9 (S)-isopropyl pivaloyloxymethyl 1-(tert-butyldimethylsilyl)-2-(tert-butyldimethylsilyloxymethyl)-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate 
• 174840-09-6 (S)-isopropyl pivaloyloxymethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-6-methyl-3,5-pyridinedicarboxylate 
• 125729-31-9 (S)-isopropyl 1,4-dihydro-2-carbamoyloxymethyl-4-(2,3-dichlorophenyl)-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate 
• 125729-30-8 (R)-isopropyl 1,4-dihydro-2-carbamoyloxymethyl-4-(2,3-dichlorophenyl)-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate 
• 144686-70-4 (S)-isopropyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-3-methoxycarbonyl-6-methyl-5-pyridinecarboxylate 
• 144686-69-1 (R)-isopropyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-3-methoxycarbonyl-6-methyl-5-pyridinecarboxylate 

Relevant academic research and scientific papers

Asymmetric synthesis of (R)-nilvadipine and (S)-NB 818 via regioselective bromination of chiral 1,4-dihydropyridines as a key step and enzymatic resolution of racemic 2-hydroxymethyl-1,4-dihydropyridine derivatives

Optically active 2-hydroxymethyl-1,4,dihydropyridines were obtained by lipase-catalyzed hydrolysis or transesterification of racemic materials. Chiral NB 818 and nilvadipine have been synthesized from chiral 2- hydroxymethyl-1,4-dihydropyridine. On the ot

Lipase AH-catalyzed asymmetric synthesis of (S)-(-)-NB 818

The first lipase-catalyzed asymmetric synthesis of biologically active (S)-(-)-NB818, has been achieved.