174855-56-2

Upstream product

• 159635-47-9 (R)-2-(2-tert-butoxycarbonylamino-2-methyl-propionylamino)-5-phenyl-pentanoic acid 
• 156130-68-6 2-(tert-butoxycarbonylamino)-5-phenyl-D-pentanoic acid 
• 59084-06-9 1-(2-nitrophenyl)piperazine 
• 30992-29-1 Boc-Aib-OH 
• 174855-55-1 (1-Methyl-1-{(R)-1-[4-(2-nitro-phenyl)-piperazine-1-carbonyl]-4-phenyl-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester 

Downstream Products

• 210481-92-8 [1-Methyl-1-((R)-4-phenyl-1-{4-[2-(propane-2-sulfonylamino)-phenyl]-piperazine-1-carbonyl}-butylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester 
• 210481-94-0 (2-{4-[(R)-2-(2-tert-Butoxycarbonylamino-2-methyl-propionylamino)-5-phenyl-pentanoyl]-piperazin-1-yl}-phenylsulfamoyl)-acetic acid methyl ester 
• 210481-93-9 (1-Methyl-1-{(R)-4-phenyl-1-[4-(2-trifluoromethanesulfonylamino-phenyl)-piperazine-1-carbonyl]-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester 
• 210481-91-7 (1-{(R)-1-[4-(2-Methanesulfonylamino-phenyl)-piperazine-1-carbonyl]-4-phenyl-butylcarbamoyl}-1-methyl-ethyl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis and biological activities of phenyl piperazine- based peptidomimetic growth hormone secretagogues

A new class of potent, orally active phenyl piperazine-based GH secretagogues have been discovered from attempts to mimic the arrangement of the phenyl substitutent in the spiroindanyl piperidine and spiroindoline sulfonamide privileged structures of 4 and 1, respectively. The best of these compounds, 18 (EC50 = 2.8 nM) is nearly as potent as MK-0677 for releasing GH from rat pituitary cells.