210481-91-7Relevant academic research and scientific papers
Synthesis and biological activities of phenyl piperazine- based peptidomimetic growth hormone secretagogues
Barakat, Khaled J.,Cheng, Kang,Chan, Wanda W.-S,Butler, Bridget S.,Jacks, Thomas M.,Schleim, Klaus D.,Hora Jr., Donald F.,Hickey, Gerard J.,Smith, Roy G.,Patchett, Arthur A.,Nargund, Ravi P.
, p. 1431 - 1436 (2007/10/03)
A new class of potent, orally active phenyl piperazine-based GH secretagogues have been discovered from attempts to mimic the arrangement of the phenyl substitutent in the spiroindanyl piperidine and spiroindoline sulfonamide privileged structures of 4 and 1, respectively. The best of these compounds, 18 (EC50 = 2.8 nM) is nearly as potent as MK-0677 for releasing GH from rat pituitary cells.
