174867-49-3

Upstream product

• 174867-47-1 2-<1-(benzyloxymethoxy)-1-methylethyl>-4-methylphenyl tert-butyldimethylsilylether 
• 174867-46-0 2-(1-hydroxy-1-methylethyl)-4-methylphenyl tert-butyldimethylsilylether 
• 6627-55-0 2-bromo-p-cresol 
• 67-56-1 methanol 
• 3279-26-3 methyl dichlorophosphite 
• 174867-48-2 2-<1-(benzyloxymethoxy)-1-methylethyl>-4-methylphenol 

Downstream Products

• 174867-52-8 (3,4-dichlorophenoxy)methyl 2-<1-(benzyloxymethoxy)-1-methylethyl>-4-methylphenyl methyl phosphate 
• 174867-64-2 (3,4-dichlorophenoxy)methyl 2-(1-hydroxy-1-methylethyl)-4-methylphenyl methyl phosphate 

Relevant academic research and scientific papers

Rapid intramolecular and C-O cleavage reactions of a phosphate triester catalysed by a neighbouring hydroxyl group

Three consecutive reactions are observed when the phosphate triester 6 is hydrolysed. At pH 12 M. 12 is then hydrolysed by C-O cleavage to give the diester 11. In base, the first two reactions are complete almost instantaneously, and the final phosphorus-containing products are (3,4-dichlorophenoxy)methyl methyl phosphate diester, and the methyl phosphate dianion. These must come from C-O cleavage reactions of diester 14 and the rearranged benzylic triester 15, which rapidly eliminate phosphate ester leaving groups to give the same quinone methide.