174890-57-4

Basic information

• Product Name: 2-Pyridineacetic acid, 5-nitro-, ethyl ester
• Synonyms: 2-Pyridineacetic acid, 5-nitro-, ethyl ester;(5-nitro-pyridin-2-yl)-acetic acid ethyl ester;Ethyl 2-(5-nitropyridin-2-yl)acetate
• CAS NO: 174890-57-4
• Molecular Formula: C9H10N2O4
• Molecular Weight: 210.1867
• Mol File: 174890-57-4.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Pyridineacetic acid, 5-nitro-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridineacetic acid, 5-nitro-, ethyl ester(174890-57-4)
• EPA Substance Registry System: 2-Pyridineacetic acid, 5-nitro-, ethyl ester(174890-57-4)

Safety Data

• Hazardous Substances Data: 174890-57-4(Hazardous Substances Data)

Usage

General Description

2-Pyridineacetic acid, 5-nitro-, ethyl ester is a chemical compound that belongs to the class of organic compounds known as pyridinecarboxylic acids and derivatives. Its particular structure is derived from pyridine, an aromatic heterocycle, and contains nitro and ester groups. This specific compound, with the molecular formula C9H9N2O5, is not widely documented. Therefore, little is known regarding its specific properties, uses, or hazards. Like other organic compounds in its class, it may have potential applications in various chemical, pharmaceutical, or material science contexts. However, based on its nitro group, it may also exhibit oxidative properties and should be handled with care.

Upstream product

• 60891-70-5 1,3-diethyl 2-(5-nitropyridin-2-yl)propanedioate 
• 4487-59-6 2-bromo-5-nitropyridine 
• 5418-51-9 5-nitro-2-hydroxypyridine 
• 921940-81-0 tert-butyl ethyl (5-nitropyridin-2-yl)malonate 
• 4548-45-2 2-chloro-5-nitropyridine 

Downstream Products

• 174890-58-5 ethyl 2-(5-aminopyridin-2-yl)acetate 
• 1260740-65-5 2-(5-nitropyridin-2-yl)ethanol 
• 1419602-92-8 phenyl 6-(2-(tert-butyldimethylsilyloxy)ethyl)pyridin-3-ylcarbamate 
• 1419602-94-0 1-(6-(2-(tert-butyldimethylsilyloxy)ethyl)pyridin-3-yl)-3-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)urea 
• 1419598-47-2 1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-hydroxyethyl)pyridin-3-yl)urea 
• 1419604-93-5 1-((3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-(tert-butyldimethylsilyloxy)ethyl)pyridin-3-yl)urea 
• 1419601-53-8 1-((3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-hydroxyethyl)pyridin-3-yl)urea 
• 1419604-97-9 1-((3-tert-butyl-1-(3-methoxyphenyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-(tert-butyldimethylsilyloxy)ethyl)pyridin-3-yl)urea 
• 1419601-56-1 1-((3-tert-butyl-1-(3-methoxyphenyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-hydroxyethyl)pyridin-3-yl)urea 
• 921940-82-1 ethyl 2-(5-[[(tert-butoxy)carbonyl]amino]pyridin-2-yl)acetate 

Relevant articles and documents

Copper-Catalyzed Bisannulations of Malonate-Tethered O-Acyl Oximes with Pyridine, Pyrazine, Pyridazine, and Quinoline Derivatives for the Construction of Dihydroindolizine-Fused Pyrrolidinones and Analogues

A copper-catalyzed bisannulation reaction of malonate-tethered O-acyl oximes with pyridine, pyrazine, pyridazine, and quinoline derivatives has been developed for the concise synthesis of structurally novel dihydroindolizine-fused pyrrolidinones and their analogues. The present reaction shows excellent regioselectivity and stereoselectivity. Theoretical calculations reveal that the coordination effect of the carbonyl group in the nucleophilic substrate determines the excellent regioselectivity. Further functionalization of the generated dihydroindolizine-fused pyrrolidinone could be easily realized through substitution, Michael addition, selective aminolysis, and hydrolysis reactions.

HETEROCYCLIC COMPOUND

The present invention provides an agent for the prophylaxis or treatment of autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus etc.) and the like, which has a superior Tyk2 inhibitory action. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

INHIBITORS OF CYTOMEGALOVIRUS

Compounds of Formula (I) wherein n, R1, R1A, R2, R4 and Z are defined herein, are useful for the treatment of cytomegalovirus disease and/or infection.