921940-82-1

Basic information

• Product Name: ethyl 2-(5-((tert-butoxycarbonyl)amino)pyridin-2-yl)acetate
• Synonyms: ethyl 2-(5-((tert-butoxycarbonyl)amino)pyridin-2-yl)acetate;Methyl 5-(Boc-amino)pyridine-2-acetate
• CAS NO: 921940-82-1
• Molecular Formula: C14H20N2O4
• Molecular Weight: 280.33
• Mol File: 921940-82-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 345.2±32.0 °C(Predicted)
• Appearance: /
• Density: 1.163±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.71±0.70(Predicted)
• CAS DataBase Reference: ethyl 2-(5-((tert-butoxycarbonyl)amino)pyridin-2-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(5-((tert-butoxycarbonyl)amino)pyridin-2-yl)acetate(921940-82-1)
• EPA Substance Registry System: ethyl 2-(5-((tert-butoxycarbonyl)amino)pyridin-2-yl)acetate(921940-82-1)

Safety Data

• Hazardous Substances Data: 921940-82-1(Hazardous Substances Data)

Usage

General Description

Ethyl 2-(5-((tert-butoxycarbonyl)amino)pyridin-2-yl)acetate is a chemical compound with the molecular formula C15H21N3O4. It is a pyridine derivative and contains an ethyl ester group. The compound also has a tert-butoxycarbonyl (Boc) protecting group attached to an amino group. Ethyl 2-(5-((tert-butoxycarbonyl)amino)pyridin-2-yl)acetate is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It is also used in research and chemical processes related to the development of new drugs and materials.

Upstream product

• 174890-58-5 ethyl 2-(5-aminopyridin-2-yl)acetate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 921940-81-0 tert-butyl ethyl (5-nitropyridin-2-yl)malonate 
• 174890-57-4 ethyl 2-(5-nitropyridin-2-yl)acetate 
• 60891-70-5 1,3-diethyl 2-(5-nitropyridin-2-yl)propanedioate 
• 4548-45-2 2-chloro-5-nitropyridine 

Downstream Products

• 1260802-13-8 tert-butyl N-[6-(2-hydroxyethyl)pyridin-3-yl]carbamate 

Relevant articles and documents

Making method of t-butyloxycarboryl-3-(hydroxymethyl)-[1,2,3]triazole[1,5-a]piperidine-6-amide

The invention relates to a synthesis method of t-butyloxycarboryl-3-(hydroxymethyl)-[1,2,3]triazole[1,5-a]piperidine-6-amide. The technical problem that a suitable industrial synthesis method does not exist at present is mainly solved. The synthesis method is divided into the following seven steps of firstly making (2-chloro-5-nitropyridine) and t-butyl ethyl malonate react in a solvent tetrahydrofuran under the action of NaH to obtain a compound 2; obtaining a compound 3 from the compound 2 under the action of trifluoroacetic acid; afterwards, subjecting the compound 3 to a hydrogenation reaction under the catalysis of palladium carbon to obtain a compound 4; carrying out t-butyloxycarboryl protection on the compound 4 to obtain a compound 5; making the compound 5 act with p-ABSA (p-Acetamidobenzenesulfonyl Azide) under the action of DBU (1,8-Diazabicyclo[5,4,0]undec-7-ene) to obtain a compound 6; reducing the compound 6 in the tetrahydrofuran by lithium aluminium tetrahydride to obtain a compound 7; subjecting the compound 7 to catalytic hydrogenation under the catalysis of wet palladium carbon to obtain a final compound 8.

INDAZOLECARBOXAMIDE DERIVATIVES AS 5HT4 RECEPTOR AGONISTS

This invention relates to compounds of the formula (I): or pharmaceutically acceptable salts thereof, wherein: R1, R2, R3, A and m are each as described herein and compositions containing such compounds and the use of such