60891-70-5

Usage

Uses

Used in Pharmaceutical Industry:
DIETHYL (5-NITROPYRIDIN-2-YL)MALONATE is used as a building block for the synthesis of various pharmaceuticals. Its reactivity in organic synthesis allows for the formation of heterocyclic compounds, which are important in the development of new drugs.
Used in Agrochemical Industry:
DIETHYL (5-NITROPYRIDIN-2-YL)MALONATE is also used as a building block in the synthesis of agrochemicals. Its ability to form heterocyclic compounds makes it a valuable component in the development of new pesticides and other agricultural chemicals.

Upstream product

• 4548-45-2 2-chloro-5-nitropyridine 
• 996-82-7 sodium diethylmalonate 
• 4487-59-6 2-bromo-5-nitropyridine 
• 105-53-3 diethyl malonate 
• 5418-51-9 5-nitro-2-hydroxypyridine 

Downstream Products

• 67515-76-8 methyl 5-amino-2-pyridinecarboxylate 
• 921940-82-1 ethyl 2-(5-[[(tert-butoxy)carbonyl]amino]pyridin-2-yl)acetate 
• 174890-58-5 ethyl 2-(5-aminopyridin-2-yl)acetate 
• 1072103-29-7 5-morpholinopicolinic acid 
• 29682-14-2 5-nitro-pyridine-2-carboxylic acid methyl ester 
• 217302-90-4 5-nitro-2-propylpyridine 
• 21203-68-9 2-methyl-5-nitropyridine 
• 1419601-56-1 1-((3-tert-butyl-1-(3-methoxyphenyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-hydroxyethyl)pyridin-3-yl)urea 
• 1419604-97-9 1-((3-tert-butyl-1-(3-methoxyphenyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-(tert-butyldimethylsilyloxy)ethyl)pyridin-3-yl)urea 
• 1419601-53-8 1-((3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-hydroxyethyl)pyridin-3-yl)urea 
• 1419604-93-5 1-((3-tert-butyl-1-(3-fluorophenyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-(tert-butyldimethylsilyloxy)ethyl)pyridin-3-yl)urea 
• 1419598-47-2 1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(2-hydroxyethyl)pyridin-3-yl)urea 
• 1419602-94-0 1-(6-(2-(tert-butyldimethylsilyloxy)ethyl)pyridin-3-yl)-3-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)urea 
• 1419602-92-8 phenyl 6-(2-(tert-butyldimethylsilyloxy)ethyl)pyridin-3-ylcarbamate 

Relevant academic research and scientific papers

As neuroprotective agents of pharmaceutical compounds

The invention discloses a medicinal compound as a neuroprotective agent. The medicinal compound is a neuronal nitric oxide synthase-postsynaptic density protein 95 (nNOS-PSD95) decoupling agent. The medicinal compound is a benzene ring derivative shown in the general formula (I) or its pharmaceutically acceptable salt. The invention further discloses a preparation method of the medicinal compound and a use of the medicinal compound in prevention and treatment on neuronal damage influence-caused diseases.

QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR INHIBITORS

Compounds of formula (Ι') that are Fibroblast Growth Factor Inhibitors (FGFR) and are therefore useful for the treatment of diseases treatable by inhibition of FGFR are disclosed. Also disclosed are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

SUBSTITUTED HETEROCYCLIC AZA DERIVATIVES

The invention relates to heterocyclic aza derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Substituted Heterocyclic Aza Compounds

Heterocyclic aza compounds as vanilloid receptor ligands, pharmaceutical compositions containing these compounds and also methods of using these compounds for the treatment and/or inhibition of pain and further diseases and/or disorders.

SUBSTITUTED HETEROAROMATIC PYRAZOLE-CONTAINING CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS

The invention relates to substituted heteroaromatic pyrazole-containing carboxamide and urea derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Substituted Heteroaromatic Pyrazole-Containing Carboxamide and Urea Compounds as Vanilloid Receptor Ligands

Substituted heteroaromatic pyrazole-containing carboxamide and urea compounds as vanilloid receptor ligands, pharmaceutical compositions containing these compounds and also to a method of using these compounds for treating and/or inhibiting pain and further diseases and/or disorders.

Modification and optimization of the bis-picolylamide-based relay protection for carboxylic acids to be cleaved by unusual complexation with Cu2+ salts

A simple modification of our recently published protection scheme for carboxylic acids as amides resulted in a new protecting group with significantly improved properties. It requires shorter reaction times for deprotection and allows us to replace Cu(OTf)2 by CuCl2, indicating at the same time the importance of the nature of the anion of the Cu2+ source. Since the new scheme fulfills all criteria required for an ideal protection group it should find widespread application in synthetic organic chemistry.

N1-PYRAZOLOSPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS

The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt of the compound, wherein R1, R2, R3 and R4 are as described herein; pharmaceutical compositions there-of; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl- CoA carboxylase enzyme(s) in an animal

N2-PYRAZOLOSPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS

The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt of said compound, wherein R1, R2, R3 and R4 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl- CoA carboxylase enzyme(s) in an animal.

PROCESS FOR PRODUCTION OF NONNATURAL AMINO ACIDS AND INTERMEDIATES THEREFOR

A process for the preparation of a nonnatural amino acid represented by the following formula (C): which is characterized by reacting a compound represented by the following formula (A1), a compound represented by the following formula (A2) and a compoun