174911-15-0Relevant academic research and scientific papers
Synthesis and biological activity of a model disaccharide containing a key unit in heparin for binding to platelets
Suda, Yasuo,Bird, Karyn,Shiyama, Takaaki,Koshida, Shuhei,Marques, Dalila,Fukase, Koichi,Sobel, Michael,Kusumoto, Shoichi
, p. 1053 - 1056 (2007/10/03)
To determine the specific site(s) in heparin necessary for binding to platelets, synthesis of a model compound containing the disaccharide sequence, O-(2-deoxy-2-sulfamido-6-O-sulfo-α-D-glucopyranosyl)-(1→4)-2-O-sulfo- α-L-idopyranuronic acid, found in heparin was performed by α-selective glycosidation using a phenyl thioglycoside as a donor. The compound inhibited 125I-labelled heparin binding to human platelets to a greater extent than a heparin-derived disaccharide, obtained by the heparinase I digestion, yet contained the same number of sulfate groups per molecule.
