87326-77-0

Upstream product

• 87326-76-9 methyl 3-O-benzyl-1,2-O-isopropylidene-α-L-idofuranosiduronate 
• 22529-61-9 (1R)-1-((3aR,6S,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro(2,3-d)(1,3)dioxol-5-yl)ethane-1,2-diol 
• 103357-81-9 5-O-trifluoromethanesulfonyl-1,2-O-isopropylidene-α-D-glucofuranurono-6,3-lactone 
• 100-39-0 benzyl bromide 
• 607738-08-9 3-O-benzyl-1,2-O-isopropylidene-β-D-mannofuranose 
• 87326-75-8 (R)-((3aR,5S,6S,6aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-trifluoromethanesulfonyloxy-acetic acid methyl ester 
• 87326-74-7 (S)-((3aR,5S,6S,6aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-trifluoromethanesulfonyloxy-acetic acid methyl ester 
• 87326-73-6 (S)-methyl 2-((3aR,5R,6S,6aR)-6-(benzyloxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-2-hydroxyacetate 
• 92955-34-5 5-O-acetyl-3-O-benzyl-1,2-O-isopropylidene-6-O-trityl-α-D-glucofuranose 
• 87326-72-5 3-O-benzyl-1,2-O-isopropyridene-α-D-glucofuranuronic acid 
• 37073-70-4 1-(6-benzyloxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-2-trityloxyethanol 
• 243982-77-6 Methyl 3-O-benzyl-1,2-isopropylidene-5-O-pivaloyl-β-L-idofuranouronate 

Downstream Products

• 87326-80-5 methyl 1,2,4-tri-O-acetyl-3-O-benzyl-α-L-idopyranuronate 
• 87326-79-2 methyl 1,2,4-tri-O-acetyl-3-O-benzyl-β-L-idopyranosyluronate 
• 92955-19-6 methyl 1,2,5-tri-O-acetyl-3-O-benzyl-β-L-idofuranuronate 
• 92955-18-5 methyl 1,2,5-tri-O-acetyl-3-O-benzyl-α-L-idofuranuronate 
• 174911-14-9 (2R,3S,4S,5R)-3,5,6-Tris-benzoyloxy-4-benzyloxy-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 243982-79-8 methyl (dimethylthexylsilyl 3-O-benzyl-β-L-idopyranoside)uronate 
• 93382-47-9 methyl (acetyl 2,4-di-O-acetyl-3-O-benzyl-α,β-L-idopyranoside)uronate 
• 87326-76-9 methyl 3-O-benzyl-1,2-O-isopropylidene-α-L-idofuranosiduronate 
• 444118-44-9 1,2-O-isopropylidene-3-O-benzyl-4-O-trichloroacetyl-6-methyl-α-L-idonic acid 
• 444118-45-0 methyl 3-O-benzyl-1,2-O-cyclopentylidene-β-L-idopyranosyluronate 
• 615542-95-5 methyl 4-O-allyl-3-O-benzyl-1,2-O-isopropylidene-α-L-idopyranosiduronate 
• 615542-98-8 methyl 3,4-di-O-benzyl-1,2-O-isopropylidene-α-L-idopyranosiduronate 
• 615543-24-3 methyl 1,2-di-O-acetyl-4-O-allyl-3-O-benzyl-β-L-idopyranosiduronate 
• 615543-00-5 methyl 3-O-benzyl-1,2-O-isopropylidene-4-O-levulinoyl-α-L-idopyranosiduronate 

Relevant academic research and scientific papers

Formal synthesis of a disaccharide repeating unit (IdoA-GlcN) of heparin and heparan sulfate

A concise route to access the key disaccharide repeating unit (IdoA-GlcN) of heparan sulfate is described. The synthesis was accomplished by commercially available diacetone α-d-glucose to functional group transformations, which led to the formation of a

PROCESS FOR PREPARING HEPARINOIDS AND INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF

Processes are disclosed for the synthesis of the Factor Xa anticoagulant fondaparinux and related compounds. Protected pentasaccharide intermediates and efficient and scalable processes for the industrial scale production of fondaparinux sodium by conversion of the protected pentasaccharide intermediates via a sequence of deprotection and sulfonation reactions are provided.

AN EFFICIENT AND SCALABLE PROCESS FOR THE MANUFACTURE OF FONDAPARINUX SODIUM

The present invention relates to a process for the synthesis of the Factor Xa anticoagulent Fondaparinux and related compounds. The invention relates, in addition, to efficient and scalable processes for the synthesis of various intermediates useful in the synthesis of Fondaparinux and related compounds.

EFFICIENT AND SCALABLE PROCESS FOR THE MANUFACTURE OF FONDAPARINUX SODIUM

The present invention relates to a process for the synthesis of the Factor Xa anticoagulent Fondaparinux and related compounds. The invention relates, in addition, to efficient and scalable processes for the synthesis of various intermediates useful in the synthesis of Fondaparinux and related compounds.

SACCHARIDE STRUCTURES AND METHODS OF MAKING AND USING SUCH STRUCTURES

Described are oligosaccharides having a protecting group at two, a plurality, a majority of, or each position in the oligosaccharide which is amenable to derivatization. Collections, libraries and methods of making and using such oligosaccharides are also

Toward the assembly of heparin and heparan sulfate oligosaccharide libraries: efficient synthesis of uronic acid and disaccharide building blocks

The monosaccharide moieties found in heparin (HP) and heparan sulfate (HS), glucosamine and two kinds of uronic acids, glucuronic and iduronic acids, were efficiently synthesized by use of glucosamine hydrochloride and glucurono-6,3-lactone as starting compounds. In the synthesis of the disaccharide building block, the key issues of preparation of uronic acids (glucuronic acid and iduronic acid moieties) were achieved in 12 steps and 15 steps, respectively, without cumbersome C-6 oxidation. The resulting monosaccharide moieties were utilized to the syntheses of HP/HS disaccharide building blocks possessing glucosamine-glucuronic acid (GlcN-GlcA) or iduronic acid (GlcN-IdoA) sequences. The disaccharide building blocks were also suitable for further modification such as glycosylation, selective deprotection, and sulfation.

Compounds that bind to the interferon-gamma, preparation method thereof and medicaments containing same

Compound capable of binding to gamma-interferon (γ-IFN), chosen from the molecules corresponding to formula (I) below: in which X is a divalent spacer group that is sufficiently long to allow the two oligosaccharide fragments A and B to each bind to one of the peptide sequences 125 to 143 of the C-terminal ends of a γ-interferon (γ-IFN) homodimer, n represents an integer from 0 to 10, and for example equal to 0, 1, 2, 3, 4 or 5, and each R independently represents a hydrogen atom, an SO3? group or a phosphate group, on the condition that no SO3? group is in the 3-position of the glucosamine units of compound (I). The invention also relates to the process for preparing these compounds, to the complexes formed by these compounds and gamma-interferon, and to the medicaments comprising these compounds or complexes.

Synthesis of iduronic acid building blocks for the modular assembly of glycosaminoglycans

The modular synthesis of glycosaminoglycans requires straightforward methods for the production of large quantities of protected uronic acid building blocks. In particular, the preparation of fully differentiated iduronic acids has proven particularly cha

Modular synthesis of heparin oligosaccharides

A general, modular strategy for the first completely stereoselective synthesis of defined heparin oligosaccharides is described. Six monosaccharide building blocks (four differentially protected glucosamines, one glucuronic and one iduronic acid) were uti

New accesses to L-iduronyl synthons

(PhS)3CLi adds with a total L-ido selectivity onto 3-O-benzyl-1,2-O- isopropylidene-α-D-xylo-dialdose 2, opening the way to the most efficient preparation of 1,2,4-tri-O-acetyl-3-O-benzyl-L-iduronyl synthon 8. Alternatively, in view of combinat