174911-14-9

Upstream product

• 87326-76-9 methyl 3-O-benzyl-1,2-O-isopropylidene-α-L-idofuranosiduronate 
• 98-88-4 benzoyl chloride 
• 87326-77-0 methyl 3-O-benzyl-L-idopyranosyluronate 

Downstream Products

• 174911-15-0 (2R,3S,4S,5R,6R)-4-Benzyloxy-3,5-dihydroxy-6-methoxy-tetrahydro-pyran-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Synthesis and biological activity of a model disaccharide containing a key unit in heparin for binding to platelets

To determine the specific site(s) in heparin necessary for binding to platelets, synthesis of a model compound containing the disaccharide sequence, O-(2-deoxy-2-sulfamido-6-O-sulfo-α-D-glucopyranosyl)-(1→4)-2-O-sulfo- α-L-idopyranuronic acid, found in heparin was performed by α-selective glycosidation using a phenyl thioglycoside as a donor. The compound inhibited 125I-labelled heparin binding to human platelets to a greater extent than a heparin-derived disaccharide, obtained by the heparinase I digestion, yet contained the same number of sulfate groups per molecule.