174955-63-6

Upstream product

• 676-99-3 methylphosphonyl difluoride 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 160971-73-3 (Rp)-5'-O-DMT-thymidine-3'-O-(Se-methyl methanephosphonoselenolate) 
• 393-76-0 3,5-dinitro-4-fluorobenzotrifluoride 
• 112514-65-5 5'-O-(dimethoxytrityl)thymidine 3'-O-(2''-cyanoethylmethylphosphonothioate) 

Downstream Products

• 90814-42-9 5'-O-DMT thymidylyl (3',5')-3'-O-acetylthymidine 5'-methanephosphonate 

Relevant academic research and scientific papers

Nucleoside 3′-methylphosphonofluoridates and nucleoside 3′-methylfluoridophosphonothioates. New convenient intermediates in large scale synthesis of dinucleoside-(3′,5′)-methylphosphonates

Nucleoside 3′-methylphosphonofluoridates 3 and nucleoside 3′-methylfluoridophosphonothioates 5 for the first time are used directly in the synthesis of dinucleosidemethylphosphonates and methylphosphonothioates. The fluoridophosphonothioates 5 were separated into pure diastereomers.

New approach to the synthesis of Oligo(nucleoside methanephosphonate)s

A new method of preparation of 5′-O-DMT-(N-protected) nucleoside 3′-O-(methanephosphonofluoridates) 2 and their phosphonylating properties toward alcohols, in particular the 5′-hydroxyl groups of nucleosides (or nucleotides), is presented. Preparation of dinucleoside (37prime;,5′)-methanephosphonates 3 in solution and solid-phase synthesis of Me-Oligo 6 demonstrate the potential use of 2 as monomers.