Nucleoside 3′-methylphosphonofluoridates and nucleoside 3′-methylfluoridophosphonothioates. New convenient intermediates in large scale synthesis of dinucleoside-(3′,5′)-methylphosphonates

Article abstract of DOI:10.1016/0040-4039(95)01946-F

Nucleoside 3′-methylphosphonofluoridates 3 and nucleoside 3′-methylfluoridophosphonothioates 5 for the first time are used directly in the synthesis of dinucleosidemethylphosphonates and methylphosphonothioates. The fluoridophosphonothioates 5 were separated into pure diastereomers.