676-99-3

Basic information

• Product Name: METHYL PHOSPHONOTHIOIC DICHLORIDE
• Synonyms: Difluoro;Difluoromethylphosphine oxide;difluoromethylphosphineoxide;Methyl difluorophosphite;methyldifluorophosphite;Methylphosphonic difluoride;methylphosphonicaciddifluoride;methyl-phosphonicaciddifluoride
• CAS NO: 676-99-3
• Molecular Formula: CH₃F₂OP
• Molecular Weight: 236.1524074
• Mol File: 676-99-3.mol

Chemical Properties

• Boiling Point: 98-99°C
• Appearance: /
• Density: 1,384 g/cm3
• Vapor Pressure: 250mmHg at 25°C
• Refractive Index: 1.276
• CAS DataBase Reference: METHYL PHOSPHONOTHIOIC DICHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL PHOSPHONOTHIOIC DICHLORIDE(676-99-3)
• EPA Substance Registry System: METHYL PHOSPHONOTHIOIC DICHLORIDE(676-99-3)

Safety Data

• Statements: 34-36/37/38
• Safety Statements: 23-26-36/37/39
• RIDADR: 3265
• Hazardous Substances Data: 676-99-3(Hazardous Substances Data)

Usage

Uses

Given the highly toxic and reactive nature of METHYL PHOSPHONOTHIOIC DICHLORIDE, its primary use is in the synthesis of chemical warfare agents, such as the VX nerve agent. Due to its potential for use as a chemical weapon, it is classified as a Schedule 1 chemical under the Chemical Weapons Convention. The handling and use of MPTC are strictly controlled to mitigate the significant risks it poses to both human health and the environment.

InChI:InChI=1/CH3F2OP/c1-5(2,3)4/h1H3

Upstream product

• 676-97-1 methylphosphonic acid dichloroanhydride 
• 115-10-6 Dimethyl ether 
• 79-20-9 acetic acid methyl ester 
• 27930-69-4 methyl-phosphonic acid-chloride diethylamide 
• 74963-92-1 C₅H₁₃FNOP 
• 121-45-9 phosphorous acid trimethyl ester 
• 993-13-5 methylphosphonic acid 
• 99450-90-5 C₇H₉N₄OP 

Downstream Products

• 114619-14-6 methyl-pentyl-phosphinoyl chloride 
• 107-44-8 O-isopropyl methylphosphonofluoridate 
• 115273-69-3 cyclohexyl-methyl-phosphinoyl chloride 
• 1426-14-8 methyl-phosphonic acid-(2-dimethylamino-ethyl ester)-fluoride 
• 676-02-8 C₆H₁₅FNO₂P 
• 6180-98-9 (Fluor-dimethylarsinooxy-phosphoryl)-methan 
• 1646-72-6 (Fluor-trimethylsilyloxy-phosphoryl)-methan 
• 673-97-2 ethyl methylphosphonofluoridate 
• 756-79-6 dimethyl methane phosphonate 
• 353-88-8 O-methyl methanephosphonofluoridate 
• 1511-67-7 methylphosphonofluoridic acid 
• 101153-04-2 methyl (cyano)methylphosphonate 
• 117889-37-9 cyano-methyl-phosphinic acid ethyl ester 
• 28616-52-6 isopropyl (cyano)methylphosphonate 

Relevant articles and documents

A new microscale method for the conversion of phosphorus oxyacids to their fluorinated analogues, using cyanuric fluoride in solution and on solid support

Cyanuric fluoride, in solution or loaded onto a Wang resin, is successfully used as a fluorinating agent for phosphorus oxy acids. The reaction is very efficient with high yields and easy workup procedures, thereby in general generating products in quantitative yields. The cyanuric fluoride is proven suitable for micromolar scale synthesis of analytical standards, particularly in its resin-bound form. Taylor & Francis Group, LLC.

α-haloenamines as reagents for the conversion of phosphorus oxyacids to their halogenated analogues

Phosphorus oxyacids are converted to their halogenated analogues under mild conditions. α-Haloenamines are shown to be effective halogen transfer reagents affording good to high yields of the desired products at reaction times, in some cases, less than one minute. Georg Thieme Verlag Stuttgart.

New General Synthesis of Organophosphorus P-F Compounds via Reaction of Azolides of Phosphorus Acids with Acyl Fluorides: Novel Route to 2-Deoxynucleosidyl Phosphorofluoridates and Phosphorodifluoridates

Tetra- and tri-coordinate P-N-imidazole derivatives and their structural analogous react smoothly with acyl fluorides to give the corresponding P-F compounds an almost quantitative yield.This method has been successfully applied to produce 2-deoxynucleosidyl phosphorofluoridates and phosphorodifluoridates.