676-99-3

Basic information

• Product Name: METHYL PHOSPHONOTHIOIC DICHLORIDE
• Synonyms: Difluoro;Difluoromethylphosphine oxide;difluoromethylphosphineoxide;Methyl difluorophosphite;methyldifluorophosphite;Methylphosphonic difluoride;methylphosphonicaciddifluoride;methyl-phosphonicaciddifluoride
• CAS NO: 676-99-3
• Molecular Formula: CH₃F₂OP
• Molecular Weight: 236.1524074
• Mol File: 676-99-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 98-99°C
• Appearance: /
• Density: 1,384 g/cm3
• Vapor Pressure: 250mmHg at 25°C
• Refractive Index: 1.276
• CAS DataBase Reference: METHYL PHOSPHONOTHIOIC DICHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL PHOSPHONOTHIOIC DICHLORIDE(676-99-3)
• EPA Substance Registry System: METHYL PHOSPHONOTHIOIC DICHLORIDE(676-99-3)

Safety Data

• Statements: 34-36/37/38
• Safety Statements: 23-26-36/37/39
• RIDADR: 3265
• Hazardous Substances Data: 676-99-3(Hazardous Substances Data)

Usage

General Description

Methyl phosphonothioic dichloride, also known as MPTC, is a highly toxic and reactive organophosphorus compound used in the synthesis of chemical warfare agents such as VX nerve agent. It is a colorless to pale yellow liquid with a strong, irritating odor and is highly corrosive to skin and eyes. MPTC is extremely hazardous and poses a significant risk to human health and the environment. It is classified as a Schedule 1 chemical under the Chemical Weapons Convention due to its potential for use as a chemical weapon. Strict regulations and safety protocols are in place to control the use and handling of this dangerous chemical.

InChI:InChI=1/CH3F2OP/c1-5(2,3)4/h1H3

Upstream product

• 993-13-5 methylphosphonic acid 
• 121-45-9 phosphorous acid trimethyl ester 
• 74963-92-1 C₅H₁₃FNOP 
• 99450-90-5 C₇H₉N₄OP 
• 27930-69-4 methyl-phosphonic acid-chloride diethylamide 
• 79-20-9 acetic acid methyl ester 
• 115-10-6 Dimethyl ether 
• 676-97-1 methylphosphonic acid dichloroanhydride 

Downstream Products

• 13213-42-8 isobutyl-methyl-phosphinoyl chloride 
• 174955-63-6 5'-O-(dimethoxytrityl)thymidine 3'-O-methylphosphonofluoridate 
• 34557-54-5 methane 
• 74-85-1 ethene 
• 74-86-2 acetylene 
• 352-63-6 O-1-butylmethylfluorophosphonate 
• 673-97-2 ethyl methylphosphonofluoridate 

Relevant articles and documents

A new microscale method for the conversion of phosphorus oxyacids to their fluorinated analogues, using cyanuric fluoride in solution and on solid support

Cyanuric fluoride, in solution or loaded onto a Wang resin, is successfully used as a fluorinating agent for phosphorus oxy acids. The reaction is very efficient with high yields and easy workup procedures, thereby in general generating products in quantitative yields. The cyanuric fluoride is proven suitable for micromolar scale synthesis of analytical standards, particularly in its resin-bound form. Taylor & Francis Group, LLC.

New General Synthesis of Organophosphorus P-F Compounds via Reaction of Azolides of Phosphorus Acids with Acyl Fluorides: Novel Route to 2-Deoxynucleosidyl Phosphorofluoridates and Phosphorodifluoridates

Tetra- and tri-coordinate P-N-imidazole derivatives and their structural analogous react smoothly with acyl fluorides to give the corresponding P-F compounds an almost quantitative yield.This method has been successfully applied to produce 2-deoxynucleosidyl phosphorofluoridates and phosphorodifluoridates.

Hydroxyphosphorane Intermediates in Substitution Reactions at Phosphorus in Acyclic Phosphonofluoridates: Evidence from Nuclear Magnetic Resonance

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