175022-83-0Relevant academic research and scientific papers
Approaches to the cephalotaxine skeleton using an intramolecular heck reaction
Ikeda, Masazumi,Hirose, Ken-Ichi,El Bialy, Serry A. A.,Sato, Tatsunori,Yakura, Takayuki,Bayomi, Said M. M.
, p. 1084 - 1089 (1998)
1-[2-(o-Iodophenyl)acetyl]-2-(prop-2-enyl)-2-vinylpyrrolidine (17), upon treatment with palladium(II) acetate [Pd(OAc)2] in the presence of tripheoylphosphine and triethylamine in refluxing acetonitrile, gave the monocylization product 20 as the major product along with a small amount of the tandem cyclization product 21. On the other hand, treatment of the 1-[2- (o-iodophenyl)aeetyl]-1-azaspiro[4.4]non-8-en-7-one (25) with Pd(OAc)2, 1,3- bis-(diphenylphosphino)propane, tributylphosphine, and silver carbonate in boiling N,N-dimethylformamide afforded the cyclized product 27 in 51% yield.
Synthesis of tricyclic nitrogen-containing heterocycles by palladium-catalyzed cyclization of 2-alkenyl-N-(o-iodobenzoyl)-and 2-alkenyl-N-(o-iodophenylacetyl)-pyrrolidines
Ikeda, Masazumi,Akamatsu, Susumu,Kugo, Yasuhiro,Sato, Tatsunori
, p. 155 - 158 (2007/10/02)
The palladium-catalyzed cyclization of the 2-alkenyl-N-(o-iodobenzoyl)-and 2-alkenyl-N-(o-iodophenylacetyl)pyrrolidines gave the tricyclic nitrogen-containing heterocycles.
